Zufarisky Sarel, . (2020) EFEKTIVITAS EKSTRAK TEH HIJAU (Camellia sinensis L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL TIKUS WISTAR (Rattus norvegicus) DIABETES YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Green Tea (Camellia sinensis L.) contains flavonoid compounds, works as an anti- yslipidemia due to chronic hyperglycemia of diabetes. This study aims to determine the effectiveness of green tea extracts on reducing total cholesterol levels in alloxan-induced Wistar diabetic rats. The design of this study is true experimental. Samples were 30 male white Wistar rats, aged 8-12 weeks, weighing ± 200 g. Green tea extract doses of 200, 400, and 800 mg / kg body weight, and negative controls were given alloxan, and positive controls were given simvastatin. The treatment group except the normal group was injected with a dose of 125 mg / kg alloxan intraperitoneally and high-fat feed. After 3 days blood from the tail was measured glucose using a glucometer and cholesterol with a spectrophotometer λ = 546 nm, giving green tea extract for 16 days orally, then re-measuring blood cholesterol from the tail. The paired T test results showed there was a decrease in total cholesterol levels after treatment (p = 0,000). One Way Anova test showed that there was an effectiveness of green tea extract to reduce total cholesterol level (p=0,000). Post-Hoc Bonferroni test results exhibited giving green tea extract a dose of 400 mg / kg comparable to simvastatin (p=0.453) that best for reduce total cholesterol levels close to normal values.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No Panggil : 1610211007] [Pembimbing : Kristina Simanjuntak] [Penguji : Maria S Thadues] |
| Uncontrolled Keywords: | Alloxan, Diabetic, Green Tea, Total Cholesterol |
| Subjects: | R Medicine > RL Dermatology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Deny Wahyudin |
| Date Deposited: | 23 Jun 2022 04:32 |
| Last Modified: | 23 Jun 2022 04:32 |
| URI: | http://repository.upnvj.ac.id/id/eprint/18081 |
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