ANALISIS PERBEDAAN MARKA GEN PENUAAN MATRIX METALLOPROTEINASE-1 PADA RIBONUCLEIC ACID FIBROBLAST YANG DIINDUKSI ULTRAVIOLET B

Billyansah Rafli Putra, . (2026) ANALISIS PERBEDAAN MARKA GEN PENUAAN MATRIX METALLOPROTEINASE-1 PADA RIBONUCLEIC ACID FIBROBLAST YANG DIINDUKSI ULTRAVIOLET B. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Introduction: Deterioration in organ function due to both intrinsic and extrinsic causes characterizes the aging process. Ultraviolet B (UVB) radiation is one influence from the outside. The matrix metalloproteinase-1 gene, which codes for the collagenase enzyme, can be upregulated by exposure to ultraviolet B radiation. An accelerated aging process may result from collagen breakdown caused by an increase in matrix metalloproteinase- 1. Methods: The study was conducted in accordance with established protocols, including a genuine experimental design that included a control group that was not tested in any way other than the posttest. The data is examined for normality using the Shapiro-Wilk test and the Kruskal-Wallis test. A p-value of less than 0.05 was used to determine statistical significance. Results: The results of the Kruskal-Wallis test indicated an increase, although it was not statistically significant, with a Sig value > 0.05. Conclusion: At24,48, and 96 minutes after exposure to UVB, RNA from both UVB-uninduced and UVB-induced fibroblasts showed a rise in the aging gene marker MMP-1, but this increase was not statistically significant.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2110211048] [Pembimbing: Nurfitri Bustamam] [Penguji 1: Karina] [Penguji 2: Salman Paris Harahap]
Uncontrolled Keywords: Matriks metalloproteinase-1, Aging, Ultraviolet B.
Subjects: R Medicine > RD Surgery
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: BILLYANSAH RAFLI PUTRA
Date Deposited: 05 Sep 2026 06:50
Last Modified: 05 Sep 2026 06:50
URI: http://repository.upnvj.ac.id/id/eprint/51445

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