HUBUNGAN ANTARA INDEKS MASSA TUBUH (IMT) DAN MEROKOK DENGAN SKOR GLEASON PADA PASIEN ADENOKARSINOMA PROSTAT DI RSPAD GATOT SOEBROTO PERIODE JANUARI 2020 - OKTOBER 2023

Putri Hiddar Ayudha, . (2023) HUBUNGAN ANTARA INDEKS MASSA TUBUH (IMT) DAN MEROKOK DENGAN SKOR GLEASON PADA PASIEN ADENOKARSINOMA PROSTAT DI RSPAD GATOT SOEBROTO PERIODE JANUARI 2020 - OKTOBER 2023. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Background: Prostate adenocarcinoma is the fifth most common cancer incidence among males in Indonesia. Risk factors such as obesity and smoking contribute to the occurrence of prostate adenocarcinoma. Gleason score in prostate adenocarcinoma aims to assess the degree of tumor differentiation and determine the prognosis of patients. At RSPAD Gatot Soebroto, 70% of patients arriving are already detected with advanced-stage cancer. In previous studies, there were gaps in the relationship between Body Mass Index (BMI) and Gleason score, while research on the association between smoking and Gleason score is limited in Indonesia. The purpose of this study is to determine the relationship between Body Mass Index (BMI) and smoking with the Gleason score in prostate adenocarcinoma patients. Methods: A study was conducted on 66 patients with prostate adenocarcinoma who met the inclusion and exclusion criteria at RSPAD Gatot Soebroto during the period from January 2020 to October 2023. The study employed an analytical observational design with a cross-sectional approach. Secondary data obtained from medical records using total sampling technique were analyzed using the Spearman test. Results: Univariate analysis results indicate that the majority of patients have an overweight BMI (47,0%), a history of smoking (66,7%), and a Gleason score for prostate adenocarcinoma 8-10 (Poorly differentiated) (74,2%). Subsequently, the analysis of BMI with Gleason score in prostate adenocarcinoma shows a p-value of 0,017 with a correlation coefficient (r) of 0,294. Meanwhile, the analysis of smoking with Gleason score in prostate adenocarcinoma shows a p-value of 0,000 with a correlation coefficient (r) of 0,465. Conclusion: The majority of patients have a Gleason score for prostate adenocarcinoma of 8-10 (Poorly differentiated) with an average of 8,48 indicate a poor prognosis. Furthermore, BMI and smoking exhibit a relationship with the Gleason score in prostate adenocarcinoma.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010211010] [Pembimbing 1: Niniek Hardini] [Pembimbing 2: Nunuk Nugrohowati] [Penguji: Tuty Rizkianti]
Uncontrolled Keywords: Prostate adenocarcinoma, BMI, smoking, Gleason score
Subjects: R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Putri Hiddar Ayudha
Date Deposited: 07 Mar 2024 02:45
Last Modified: 07 Mar 2024 02:45
URI: http://repository.upnvj.ac.id/id/eprint/28314

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