Muthiah Nahda S Kembaren, . (2023) UJI EFEKTIVITAS EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L) DALAM MENGHAMBAT PERTUMBUHAN JAMUR Malassezia furfur SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
A fungus called Malassezia furfur causes the skin infection called pityriasis versicolor. The incidence rate in Indonesia is 53.2% which is the highest among other fungal skin infections. Antifungal therapy has limitations such as side effects, relapse, and fungal resistance. Therefore, there is a requirement to look for alternative therapies using traditional plants. Belimbing wuluh leaves (Averrhoa bilimbi L.) contain alkaloids, flavonoids, saponins, and tannins which can inhibit the growth of fungi. This research seeks to ascertain whether belimbing wuluh leaf extract may effectively inhibiting the growth of Malassezia furfur in vitro. Concentrations of the extract were 20%; 40%; 60%; and 80%. The test method used well-plate technique on Sabouraud Dextrose Agar media. The inhibition zone was observed after 24 and 48 hours. The Kruskal-Wallis test then Mann-Whitney Post Hoc test were used to examine the measurement results. After 24 hours, the average inhibition area was obtained at a concentration of 20%; 40%; 60%; and 80% respectively are 8.17 mm; 9.32 mm: 10.98 mm; and 13.84 mm while at 48 hours no inhibition area had formed. The Kruskal-Wallis results obtained p = 0.000 followed by the Mann-Whitney Post Hoc and it was found that almost all treatment groups had significant differences except for a concentration of 60% compared to a concentration of 80%. This research concludes that the leaf extract of belimbing wuluh (Averrhoa bilimbi L.) is effective in inhibiting the growth of Malassezia furfur fungus in vitro and the most effective concentration is 60% with strong antifungal inhibition. Saponins are secondary metabolites that play a very important role by penetrating the fungal membrane so it can be ruptured.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 1910211111] [Pembimbing 1: Yuni Setyaningsih] [Pembimbing 2: Feda Anisah Makkiyah 1] [Penguji : Meiskha Bahar] |
| Uncontrolled Keywords: | antifungal;belimbing wuluh leaves; Malassezia furfur; pityriasis versicolor |
| Subjects: | R Medicine > RL Dermatology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Muthiah Nahda Salaamah Kembaren |
| Date Deposited: | 10 Mar 2023 07:34 |
| Last Modified: | 10 Mar 2023 07:34 |
| URI: | http://repository.upnvj.ac.id/id/eprint/23090 |
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