Nur Ajiyanti Sabirina, . (2026) PENGARUH PEMBERIAN EKSTRAK BUAH KELOR (MORINGA OLEIFERA) TERHADAP PROFIL LIPID, KADAR MALONDIALDEHID (MDA) DAN HISTOPATOLOGI NEUROINFLAMASI SEL GLIA PADA TIKUS MODEL OBESITAS. Tesis thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Background: Obesity triggers systemic metaflammation and oxidative stress, leading to blood-brain barrier disruption and chronic neuroinflammation, particularly in the medial Prefrontal Cortex (mPFC). The neuroprotective potential of Moringa oleifera fruit, which is rich in lipophilic phytochemicals, remains under-explored compared to its leaves. Objective: This study aimed to analyze the effects of Moringa oleifera fruit extract on the lipid profile, malondialdehyde (MDA) levels, and mPFC neuroinflammatory histopathology in obese rat models. Methods: This experimental study utilized 24 male Wistar rats divided into four groups: Normal Control (NC), Negative Control (HFHS diet), and two treatment groups receiving Moringa oleifera fruit extract at doses of 500 mg/kgBW (KP3) and 1000 mg/kgBW (KP4). Obesity was induced for 8 weeks, followed by a 4-week treatment period. Parameters included lipid profile, mPFC MDA levels, Brain Weight Index, and glial cell density. Data were analyzed using ANOVA/Welch and Tukey's post-hoc tests (p < 0.05). Results: The HFHS diet effectively established an obesity model (Lee Index > 0.3) characterized by dyslipidemia and significantly elevated mPFC MDA levels (12.91 nmol/ml). The administration of the extract at 1000 mg/kgBW (KP4) was the most effective in improving the lipid profile, reducing MDA levels to near-normal levels (7.35 nmol/ml), and restoring the Brain Weight Index (0.592). Histopathological observation revealed that KP4 significantly mitigated the number of dark neurons and vacuolization while maintaining controlled glial cell density compared to the negative control. Conclusion: Moringa oleifera fruit extract demonstrates potent dose-dependent neuroprotective effects, with 1000 mg/kgBW as the optimal dose. This protective mechanism is mediated through the improvement of systemic lipid metabolism and attenuation of the oxidative stress-neuroinflammation cascade in the mPFC.
| Item Type: | Thesis (Tesis) |
|---|---|
| Additional Information: | [No. Panggil: 2320223007] [Pembimbing 1: Maria Selvester Thadeus] [Pembimbing 2 : Feda Anisah Makkiyah] [Penguji 1 : Muttia Amalia] [Penguji 2: Ratna Puspita] |
| Uncontrolled Keywords: | Moringa Oleifera, Obesity, mPFC, Malondialdehyde, Neuroinflammation. |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Sains Biomedis (S2) |
| Depositing User: | NUR AJIYANTI SABIRINA |
| Date Deposited: | 04 May 2026 03:27 |
| Last Modified: | 04 May 2026 03:27 |
| URI: | http://repository.upnvj.ac.id/id/eprint/49391 |
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