GAMBARAN HISTOPATOLOGI HATI TIKUS GALUR WISTAR MODEL HIPERKOLESTEROLEMIA DIABETES SETELAH PEMBERIAN EKSTRAK ETANOL BUNGA KRISAN (CHRYSANTHEMUM MORIFOLIUM).

Winnona Chandra Wijaya, . (2026) GAMBARAN HISTOPATOLOGI HATI TIKUS GALUR WISTAR MODEL HIPERKOLESTEROLEMIA DIABETES SETELAH PEMBERIAN EKSTRAK ETANOL BUNGA KRISAN (CHRYSANTHEMUM MORIFOLIUM). Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Diabetes mellitus and hypercholesterolemia are two metabolic conditions with increasing prevalence. Both conditions can lead to complications in various organs, including the liver. This study aimed to determine the effect of ethanol extract of chrysanthemum flowers (C. morifolium) on the liver histopathology of Wistar rats in a diabetic hypercholesterolemia model. This research was an experimental study using rats, with a posttest-only control group design. The research sample, namely white rats of the Wistar strain (Rattus norvegicus), was selected using a simple random sampling technique, following the inclusion and exclusion criteria. The independent variable in the study was the ethanol extract of chrysanthemum flowers at doses of 75, 150, and 300 mg/kgBW, while the dependent variable was the histopathological appearance of the liver of Wistar rats, which was assessed using the Manja-Roenigk scoring system. Data analysis used a one-way ANOVA test, followed by a Bonferroni post hoc test. The results of the one-way ANOVA test showed a significant difference between each group (sig. 0.000). The Bonferroni post hoc test showed that the treatment group had significant results compared to the negative control. The group with the Manja-Roenigk mean score closest to the normal control was treatment group 3, which was given ethanol extract of chrysanthemum flowers (C. morifolium) at a dose of 300 mg/kgBW. In the study, it was found that administering ethanol extract of chrysanthemum flowers (C. morifolium) had an effect on improving the histopathological appearance of the livers of Wistar rats in the diabetic hypercholesterolemia model, where a dose of 300 mg/kgBW was the most effective in helping improve the histopathological appearance of the livers of rats.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210211138] [Pembimbing 1: Retno Yulianti] [Pembimbing 2: Tri Faranita] [Penguji: Maria Selvester Thadeus]
Uncontrolled Keywords: Chrysanthemum morifolium, Diabetes, Hypercholesterolemia, Liver histopathology
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: WINNONA CHANDRA WIJAYA
Date Deposited: 30 Apr 2026 02:03
Last Modified: 30 Apr 2026 02:03
URI: http://repository.upnvj.ac.id/id/eprint/41659

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