Hanifah Putri Ayuni, . (2025) UJI EFEKTIVITAS ANTIFUNGI EKSTRAK AKAR TANAMAN AKAR WANGI (Chrysopogon zizanioides) DENGAN METODE ULTRASONIC ASSISTED EXTRACTION (UAE) TERHADAP PERTUMBUHAN JAMUR Malassezia furfur SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
![[img]](http://repository.upnvj.ac.id/style/images/fileicons/text.png) |
Text
ABSTRAK.pdf Download (147kB) |
![[img]](http://repository.upnvj.ac.id/style/images/fileicons/application_pdf.png) |
PDF
AWAL.PDF Download (4MB) |
|
Text
BAB 1.pdf Restricted to Repository UPNVJ Only Download (204kB) |
|
Text
BAB 2.pdf Restricted to Repository UPNVJ Only Download (4MB) |
|
Text
BAB 3.pdf Restricted to Repository UPNVJ Only Download (329kB) |
|
Text
BAB 4.pdf Restricted to Repository UPNVJ Only Download (408kB) |
|
Text
BAB 5.pdf Download (187kB) |
|
Text
DAFTAR PUSTAKA.pdf Download (229kB) |
|
Text
LAMPIRAN.pdf Restricted to Repository UPNVJ Only Download (38MB) |
|
Text
RIWAYAT HIDUP.pdf Restricted to Repository UPNVJ Only Download (2MB) |
|
Text
HASIL PLAGIARISME.pdf Restricted to Repository staff only Download (3MB) |
|
Text
ARTIKEL KI.pdf Restricted to Repository staff only Download (2MB) |
Abstract
Fungal skin infections such as Pityriasis versicolor are common dermatological problems in Indonesia, caused by the overgrowth of Malassezia furfur. Although synthetic antifungal agents like ketoconazole are effective, they may cause side effects and resistance, prompting the search for safer natural alternatives. Vetiver root (Chrysopogon zizanioides) contains active compounds such as flavonoids, tannins, and alkaloids, which are potential antifungal agents. This study aimed to determine the antifungal activity of vetiver root extract obtained through the Ultrasonic Assisted Extraction (UAE) method against M. furfur in vitro. This experimental research used a post-test only control group design with five extract concentrations (5%, 10%, 20%, 30%, and 40%) tested against M. furfur isolates on Sabouraud Dextrose Agar (SDA) medium using the well diffusion method. Ketoconazole 2% served as the positive control and DMSO as the negative control. Observations were made at 24, 48, and 72 hours. Phytochemical screening revealed the presence of alkaloids, flavonoids, and tannins. The average inhibition zone increased consistently with higher extract concentrations. The highest activity was observed at the 40% concentration (17.53 mm at 48 hours), exceeding the positive control (14.44 mm). Statistical analysis using One Way ANOVA and Kruskal-Wallis showed significant differences among treatment groups (p < 0,05). The antifungal activity is presumed to occur through membrane disruption and inhibition of protein synthesis by flavonoids and tannins. Therefore, vetiver root extract demonstrates strong potential as a natural antifungal agent against M. furfur, with its highest inhibitory effect observed at the 40% concentration after 48 hours of incubation, indicating a primarily fungistatic mode of action.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2210211233] [Pembimbing 1 : Yuni Setyaningsih] [Pembimbing 2 : Riezky Valentina Astari] [Penguji : Muttia Amalia] |
| Uncontrolled Keywords: | Antifungal, Malassezia furfur, Pityriasis versicolor, Ultrasonic Assisted Extraction, Vetiver root extract, Well diffusion. |
| Subjects: | Q Science > Q Science (General) Q Science > QK Botany Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | HANIFAH PUTRI AYUNI |
| Date Deposited: | 06 May 2026 05:24 |
| Last Modified: | 06 May 2026 05:24 |
| URI: | http://repository.upnvj.ac.id/id/eprint/41116 |
Actions (login required)
 |
View Item |