Maysa Hanifauzya, . (2025) VALIDASI METODE ANALISIS PENETAPAN KADAR ASAM RETINOAT DALAM KRIM ANTI AGING DI E-COMMERCE DENGAN KROMATOGRAFI CAIR KINERJA TINGGI. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Retinoic acid is an effective compound widely used in anti aging cream products due to its ability to accelerate skin regeneration. However, the illegal use of retinoic acid in cosmetics without distribution permits is still frequently found in e-commerce platforms. This study aims to validate an analytical method for determining the concentration of retinoic acid using High Performance Liquid Chromatography (HPLC) and to analyze its concentration in anti aging cream samples. The research was conducted using an eluent composition of methanol:water:glacial acetic acid (70:30:0.5) on an HPLC instrument equipped with a C18 column and a flow rate of 1 mL/min. The method validation results showed that the parameters for linearity, accuracy, precision, range, and specificity met the ICH guidelines. Identification using Thin Layer Chromatography (TLC) revealed that 5 out of 18 tested anti aging cream samples were positive for retinoic acid content. Quantitative analysis using HPLC indicated that the retinoic acid concentrations in the positive samples were as follows: 0,0034% (S1); 0,0008% (S3); 0,0007% (T6); 0,0021% (L3); and 0,0024% (L4). A significance test using the Kruskal-Wallis method yielded a p value of <0.05, indicating a significant difference in retinoic acid concentrations among samples S1, S3, T6, L3, and L4.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2110212030] [Pembimbing Utama/Ketua Sidang: Rika Revina] [Pembimbing Pendamping/Penguji 2: Via Rifkia] [Penguji Utama/Penguji 1: Aulia Farkhani] |
| Uncontrolled Keywords: | Anti Aging Cream, HPLC, Method Validation, Retinoic Acid, TLC |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | MAYSA HANIFAUZYA |
| Date Deposited: | 15 Aug 2025 08:18 |
| Last Modified: | 15 Aug 2025 08:18 |
| URI: | http://repository.upnvj.ac.id/id/eprint/38172 |
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