PENGARUH PEMBERIAN EKSTRAK DAUN MELINJO (Gnetum gnemon L.) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS WISTAR JANTAN MODEL HIPERURISEMIA

Khalissa Virly Hanaputri, . (2024) PENGARUH PEMBERIAN EKSTRAK DAUN MELINJO (Gnetum gnemon L.) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS WISTAR JANTAN MODEL HIPERURISEMIA. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Efforts to find alternative therapies for hyperuricemia, which still has a high prevalence rate, are carried out with the aim of minimizing side effects, one of which is using natural-based medicines such as the melinjo. Melinjo leaf extract (Gnetum gnemon L.)’ contains zflavonoids and other secondary jmetabolite[ compounds that have the potential as antihyperuricemia. Thisl studyoaims to determine the ‘effect of melinjo leaf jextract xon reducing uric acid plevels in male bWistar rats used as a hyperuricemia model. The research used true experimental study with a ‘pretest-posttestd control group design. A total of 30 male Wistar rats weighing 180-200g and aged 6-8 weeks were provided from the UNPAD farm, in Bandung. Rats were grouped using a simple random sampling method into 5 groups, namely K(-) {standard feed and drink}, K(+) {allupurinol 10mg/kgBW}, and P1, P2, P3 {gnetum gnemon leaf extract doses of 20, 40, and 80mg/kgBW}. The treatment period was 14 days with 7 days of acclimatization. Examination of uric acid levels using blood samples taken through the rat's tail vein. The ‘results of the yPaired T-Test showed that there was an effect of gnetum gnemon leaf extract on reducing urick acid olevels in male Wistar rats with a hyperuricemia model (P = 0.000). The Bonferroni Post-Hoc test analysis concluded that melinjo leaf extract at a dose of 40mg/kgBW pwas the most effective’ dose in reducing uric acid levels in rats

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2110211076] [Pembimbing 1: Erna Harfiani] [Pembimbing 2: Yanti Harjono Hadiwiardjo] [Penguji: Retno Yulianti]
Uncontrolled Keywords: Melinjo Leaf Extract, Uric Acid, Antihyperuricemic
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: KHALISSA VIRLY HANAPUTRI
Date Deposited: 13 Feb 2025 06:38
Last Modified: 13 Feb 2025 06:38
URI: http://repository.upnvj.ac.id/id/eprint/34743

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