PENGARUH TERAPI KLOZAPIN DAN RISPERIDONE TERHADAP KADAR GLUKOSA DARAH PADA PASIEN RAWAT INAP SKIZOFRENIA KOMORBID DIABETES MELITUS TIPE 2 DI RSJ DR. H. MARZOEKI MAHDI BOGOR TAHUN 2023”

Zhea Shafira Aqilla Sunardi, . (2023) PENGARUH TERAPI KLOZAPIN DAN RISPERIDONE TERHADAP KADAR GLUKOSA DARAH PADA PASIEN RAWAT INAP SKIZOFRENIA KOMORBID DIABETES MELITUS TIPE 2 DI RSJ DR. H. MARZOEKI MAHDI BOGOR TAHUN 2023”. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Schizophrenia is a chronic mental disorder impacting thoughts, perceptions, emotions, language, feelings, and behavior, leading to significant changes in cognitive and behavioral patterns. Patients with schizophrenia have a higher susceptibility to type 2 diabetes mellitus (T2DM) compared to the general population. Atypical antipsychotics, such as clozapine and risperidone, are the primary treatment option for managing schizophrenia through neurotransmitter modulation. However, these medications often entail serious metabolic side effects, including obesity, type 2 DM, and hyperglycemia. This study aimed to investigate the effects of clozapine and risperidone therapy on blood glucose levels in patients with schizophrenia and T2DM at dr. H. Marzoeki Mahdi Psychiatric Hospital in Bogor. Twenty-two patients participated in the study, with data analysis employing hypothesis testing for differences in proportions between groups and One-Way ANOVA. The findings indicated that both clozapine and risperidone therapies, either alone or combined, increased blood glucose levels significantly (P=0.002). Patients using atypical antipsychotics without antidiabetic medication showed a rise in blood glucose levels from 139 mg/dl to 178 mg/dl. In conclusion, a greater elevation in fasting blood glucose levels was observed in patients undergoing clozapine therapy compared to those receiving risperidone at dr. H. Marzoeki Mahdi Psychiatric Hospital in Bogor

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010212054] [Pembimbing 1 : Eldiza Puji Rahmi] [Pembimbing 2: Dhigna Luthfiyani C.P.] [Penguji 1: Annisa Farida Muti]
Uncontrolled Keywords: Blood Glucose Levels, Clozapine, and Risperidone, Schizophrenia, and Type 2 Diabetes Melitus (T2DM)
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Program Studi Farmasi (S1)
Depositing User: ZHEA SHAFIRA AQILLA SUNARDI
Date Deposited: 09 Sep 2024 03:48
Last Modified: 09 Sep 2024 03:48
URI: http://repository.upnvj.ac.id/id/eprint/32592

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