Benneth Djodi Simangunsong, . (2024) AKTIVITAS ANTIBIOFILM EKSTRAK ETANOL DAN MINYAK ATSIRI BUAH ANDALIMAN (ZANTHOXYLUM CANTHOPODIUM DC) TERHADAP STREPTOCOCCUS MUTANS DAN CANDIDA ALBICANS. Tugas Akhir thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Biofilm is a health issue causing various oral problems. According to 2018 health research, Streptococcus mutans and Candida albicans are common microorganisms that cause biofilm growth leading to infections. Chlorhexidine, a common antiseptic for oral infections, has side effects like tooth discoloration, skin peeling, and taste disturbances. This study evaluates the antibiofilm effects of ethanol extract and essential oil from andaliman fruit (Zanthoxylum acanthopodium DC). Ethanol extraction used Ultrasonic Assisted Extraction (UAE), while essential oil extraction used hydrodistillation. The antibacterial testing employed the Minimum Inhibitory Concentration (MIC) method, biofilm inhibition was measured by optical density (OD) using a microplate reader, and IC50 values were calculated. Both ethanol extract and essential oil showed MIC values of 500 ppm. The lowest OD was achieved by both at 500 ppm. The IC50 value of the ethanol extract was better at inhibiting Streptococcus mutans biofilm at 265 ppm, while both had the same IC50 value at 262 ppm for Candida albicans. Independent-samples T-test showed no significant difference between the ethanol extract and essential oil against Streptococcus mutans (0.665; p > 0,05) and Candida albicans (0.997; p > 0,05).
| Item Type: | Thesis (Tugas Akhir) |
|---|---|
| Additional Information: | [No.Panggil: 2010212038] [Pembimbing: Dhigna Luthfiyani Citra Pradana] [Penguji 1: Eldiza Puji Rahmi [Penguji 2: Annisa Farida Muti] |
| Uncontrolled Keywords: | Biofilm, Candida albicans, IC50, Streptococcus mutans, Zanthoxylum acanthopodium DC |
| Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | BENNETH DJODI SIMANGUNSONG |
| Date Deposited: | 10 Sep 2024 02:39 |
| Last Modified: | 10 Sep 2024 02:39 |
| URI: | http://repository.upnvj.ac.id/id/eprint/32478 |
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