Fiandra Ratna Kesuma, . (2023) PENGARUH PEMBERIAN EKSTRAK KULIT TERUNG UNGU (Solanum melongena L.) TERHADAP KADAR MALONDIALDEHID (MDA) PADA MODEL TIKUS DIABETES. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Diabetes mellitus with chronic hyperglycemia causes elevation of free radicals level that trigger lipid peroxidation to generate MDA and disease-induced oxidative stress. Alternative therapy using purple eggplant skin (Solanum melongena L.) contains flavonoids as antioxidants can reduce free radicals. The objective of this study was to assess the effect of purple eggplant skin extract (EKTU) on malondialdehyde (MDA) in plasma of diabetic Wistar rats. Experimental research using posttest only control group design. Samples of 30 Wistar rats, males, weighing 150-200 grams, and 2-3 months were collected by simple random sampling. Samples were divided into K1 (standard diet, distilled water), K2 (high-fat diet, alloxan), K3 (high-fat diet, alloxan, metformin), and K4, K5, K6 {high-fat diet, alloxan, purple eggplant skin extract doses of 75, 150, 300 (mg/kgBB)}, with 14 days treatment. Rats were anesthetized with ketamine xylazine, blood was drawn into tubes then sentrifuged to produce plasma, and MDA was measured using a spectrophotometer with 532 nm. One-Way Annova test results showed that there was an effect of purple eggplant skin extract on plasma malondialdehyde levels of diabetic Wistar rats (p=0,000). Bonferroni Post-Hoc test indicated the purple eggplant skin extract dose of 300 mg/kgBB was almost the same effect as normal (p=1,000). Purple eggplant skin extract can lower malondialdehyde (MDA) levels in diabetic Wistar rats.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2010211020] [Pembimbing 1: Kristina Simanjuntak] [Pembimbing 2: Cut Fauziah] [Penguji: Retno Yulianti] |
| Uncontrolled Keywords: | Diabetes mellitus, Free radicals, Malondialdehyde, Purple eggplant skin extract |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Fiandra Ratna Kesuma |
| Date Deposited: | 14 Mar 2024 02:12 |
| Last Modified: | 14 Mar 2024 02:12 |
| URI: | http://repository.upnvj.ac.id/id/eprint/28364 |
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