Arini Raissa Arintoko, . (2024) PERBANDINGAN PROFIL SEL IMUN DARI PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) PASIEN KANKER STADIUM LANJUT DENGAN RIWAYAT KEMOTERAPI DAN NON KEMOTERAPI YANG AKAN MENJALANI IMMUNE CELL THERAPY (ICT) DI KLINIK HAYANDRA TAHUN 2020 - 2023. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Cancer is a condition where abnormal cells divide uncontrollably, potentially spreading throughout the body, particularly in advanced stages. In Indonesia, cancer is a significant cause of death, with 80% of individuals being diagnosed at an advanced stage, leading to a considerable social and economic burden. Despite chemotherapy being one of the cancer treatments, its side effects, such as halting the production of leukocytes by the bone marrow as the body's immune system, can undermine the antitumor response. As a supporting therapy, Immune Cell Therapy (ICT) employs culturing techniques using immune cells from the patient's body to selectively target and eliminate cancer cells without causing harm to normal cells. However, there is still a lack of research on the use and benefits of ICT, particularly concerning immune cells in cancer patients with a history of primary therapy, prompting further investigation at the Hayandra Clinic in Jakarta. This study aims to compare the immune cell profiles of Peripheral Blood Mononuclear Cells (PBMC) in advanced cancer patients with a history of chemotherapy and non-chemotherapy, who will undergo ICT at the Hayandra Clinic between 2020 to 2023. This study employed observational analytical methods and a cross-sectional design, employing a total sampling technique consisting of 20 medical records meeting the research's restriction criteria. The research data were analyzed using the independent-sample T-test for comparing means. The results revealed that the highest average percentage of Peripheral Blood Mononuclear Cells (PBMC) was identified in the CD3-/CD8- expression (7.41%) overall, CD3-/CD19- (7.50%) for the group with a history of chemotherapy, and CD3-/CD8- (7.38%) for the non-chemotherapy group. The average pure CD3+ expression from all PBMCs in the chemotherapy history group was 5.76%, while in the non-chemotherapy history group, it was 6.37%. The results of the statistical test analysis, specifically the independent-sample T-test, indicated a p-value > 0.05. The conclusion of the study showed that there was no statistically significant difference in the PBMC immune cell profile between the group of advanced cancer patients with a history of chemotherapy and the non-chemotherapy group who will undergo Immune Cell Therapy (ICT) at the Hayandra Clinic from 2020 to 2023. Nevertheless, the average percentage of pure CD3+ expression from all PBMCs in the non-chemotherapy history group exceeded that of the chemotherapy history group.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 2010211017] [Pembimbing 1: Karina] [Pembimbing 2: Diana Agustini P] [Penguji: Niniek Hardini] |
| Uncontrolled Keywords: | Peripheral Blood Mononuclear Cells (PBMC), advanced cancer, chemotherapy, Immune Cell Therapy (ICT), Cluster of Differentiation (CD) |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RD Surgery |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Arini Raissa Arintoko |
| Date Deposited: | 15 Mar 2024 08:10 |
| Last Modified: | 15 Mar 2024 08:10 |
| URI: | http://repository.upnvj.ac.id/id/eprint/28306 |
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