Marwah Widhawati, . (2022) POTENSI DELIMA (PUNICA GRANATUM) SEBAGAI HEPATOPROTEKTOR TERHADAP PERBAIKAN HISTOPATOLOGI HEPAR PADA KEADAAN HEPATOTOKSISITAS IMBAS OBAT SECARA IN VIVO : SYSTEMATIC LITERATURE REVIEW. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Background: Consumption of foreign compounds (xenobiotics) can cause drug-induced hepatotoxicity (drug-induced liver injury, DILI). Drug-induced hepatotoxicity is a major cause of acute liver failure and can develop to chronic liver injury and able to become a liver failure. High level of ROS and oxidative stress on DILI can induce cell death as well as increased inflammation. Pomegranate (Punica granatum) as an antioxidant and anti-inflammatory can be an alternative option for DILI treatment. The aim of this study is to assess the potential of pomegranate as a hepatoprotector to improve histopathology of the liver in the state of drug-induced hepatotoxicity in vivo. Methods: A systematic review was done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2015. Database used was PubMed and Google Scholar which discusses about pomegranate, hepatotoxicity, and histopathology. Results: 2 out of 10 journals researched and demonstrated a reduction in apoptosis due to pomegranate administration. 9 out of 10 journals investigated the reduction of necrosis of which 7 of them showed a reduction of necrosis. In addition, of the 10 journals reviewed, 8 of them showed a reduction in inflammatory cell infiltration. Conclusion: Pomegranate contain antioxidant compounds and can function as anti-inflammatory as well as being able to modulate the expression of apoptosis-related proteins potential as hepatoprotector that can improve the histopathological image of the liver in the state of drug-induced hepatotoxicity in vivo in the form of reduction of apoptosis, necrosis, and inflammatory cell infiltration if the dose and time of administration used with the right method.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 1710211098] [Pembimbing: Niniek Hardini] [Penguji 1: Mila Citrawati] |
| Uncontrolled Keywords: | Pomegranate, drug, hepatotoxicity, hepatoprotective, histopathology |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Marwah Widhawati |
| Date Deposited: | 21 Feb 2022 03:57 |
| Last Modified: | 21 Feb 2022 03:57 |
| URI: | http://repository.upnvj.ac.id/id/eprint/16459 |
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