Ameliana, . (2022) TERAPI BEDAH PEMANJANGAN TUNGKAI VS TERAPI OBAT HORMONAL VOSORITIDE PADA PENDERITA AKONDROPLASIA : SYSTEMATIC REVIEW. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Introduction: Achondroplasia is a bone growth disorder caused by mutations in the fibroblast growth factor-receptor-3 (FGFR-3) gene that causes the body to be short and disproportionate. This condition can be modified bylimb lengthening therapyother hand, various studies to date have shown that the C-natriuretic peptide (vosoritide) analogue is a promising therapy to increase the height of patients with achondroplasia. This review aims to determine the effectiveness and safety of both therapies. Methods: The literature search process was carried out using the SCOPUS, Pubmed, Science direct, Google Scholar, DOAJ databases. Results: In systematic review , based on 5 research literatures that have been selected using the PRISMA-P method, it shows that limb lengthening surgical therapy increases height with an average height gain that is almost as planned. In 4 literatures with vosoritide increase in growth rate was obtained up to 5.52 cm/year. The complication rate after limb lengthening surgery was higher than vosoritide with no complications found in the literature. Conclusion: Surgical treatment of limb lengthening increases the height of patients with achondroplasia more quickly but the complications caused are not lower than that of the hormonal drug vosoritide.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | {No Panggil: 1810211031} {Penguji: dr. Pritha Maya Savitri] [Pembimbing 1: Basuki Supartono] [Pembimbing 2: Hany Yusmaini,] |
| Uncontrolled Keywords: | Achondroplasia, Limb lengthening, C-natriuretic peptide analogue, Therapy, Effectivity, Safety. |
| Subjects: | R Medicine > RD Surgery R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Ameliana - |
| Date Deposited: | 10 Feb 2022 06:25 |
| Last Modified: | 11 Feb 2022 08:26 |
| URI: | http://repository.upnvj.ac.id/id/eprint/16286 |
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