Naufal Hazmi Artana, . (2026) PENGARUH EKSTRAK DAUN NANGKA (Artocarpus heterophyllus) TERHADAP PERTUMBUHAN Trichophyton rubrum SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Objective Trichophyton rubrum is a dermatophyte fungus that is one of the main causes of dermatophytosis. The use of synthetic antifungal drugs to treat dermatophytosis can lead to resistance and may cause various adverse effects. Jackfruit leaves contain various bioactive compounds such as flavonoids, alkaloids, saponins, and tannins that have been proven to have antifungal properties. To acquire the bioactive compounds, Ultrasound-Assisted Extraction was performed due to its efficiency in extracting such compounds. The aim of this study is to determine the effect of jackfruit leaf extract on inhibiting the growth of T. rubrum. Method Jackfruit leaf extract concentrations of 50%, 60%, 70%, 80%, and 90% were the independent variables in this pure experimental study with a post-test only control group design. The dependent variable was the fungal growth inhibition zone. The positive control was ketoconazole 2%. The well diffusion method was employed in this study and observations were made at 24 and 48 hours. Result The results indicate that jackfruit leaf extract produces an inhibitory zone against T. rubrum due to the bioactive compounds that act as a fungistatic agent that increases with higher extract concentration. Statistically, extract concentration of 80% is the most effective in inhibiting T. rubrum growth with concentration of 90% showing no significant increase in antifungal efficacy. Conclusion Based on the results of the study, it was found that jackfruit leaf extract at a certain concentration can inhibit the growth of T. rubrum, with an extract concentration of 80% being the most effective concentration.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2210211129] [Pembimbing 1: Yuni Setyaningsih] [Pembimbing 2: Meiskha Bahar] [Penguji: Muttia Amalia] |
| Uncontrolled Keywords: | Antifungal, Jackfruit leaves, Trichophyton rubrum, Inhibition zone, Ultrasound-Assisted Extraction (UAE) |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RL Dermatology R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | NAUFAL HAZMI ARTANA |
| Date Deposited: | 04 May 2026 02:37 |
| Last Modified: | 04 May 2026 02:37 |
| URI: | http://repository.upnvj.ac.id/id/eprint/41813 |
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