Veronika Christi Yosanda, . (2025) PENGARUH PEMBERIAN EKSTRAK BUAH KELOR (Moringa oleifera fruits) TERHADAP PENINGKATAN KADAR HIGH DENSITY LIPOPROTEIN (HDL) PADA TIKUS MODEL OBESITAS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Obesity is a major metabolic disorder known to reduce high-density lipoprotein (HDL) levels, a protective lipoprotein essential for cardiovascular health. This study aimed to evaluate the effect of Moringa oleifera fruit extract on HDL levels in Sprague Dawley rats induced with obesity through a high-fat, high-protein diet. The fruit part was selected due to its antioxidant potential, although it remains understudied compared to other parts of the plant. Five groups were assigned, consisting of a normal control, an obese control, a vitamin C positive control, and two treatment groups reveiving Moringa oleifera fruit extract once or twice daily for 14 days. HDL levels were analyzed using an ELISA assay. Data were processed using one-way ANOVA followed by Tukey’s HSD test. The study demonstrated a significant difference in HDL levels between groups (p = 0,001). The highest increase occured in rats receiving Moringa oleifera fruit extract twice daily at 500 mg/KgBW, showing a comparable effect to vitamin C. Once-daily dosing did not produce consistent improvement. Overall, the extract appears to enhance HDL in obesity, particularly when administered more frequently.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 2210211214] [Pembimbing 1: Tiwuk Susantiningsih] [Pembimbing 2: Yosha Putri Wahyuni] [Penguji: Kristina Simanjuntak] |
| Uncontrolled Keywords: | HDL, High-Fat High-Protein Diet, Moringa Oleifera Fruit, Obesity, Sprague Dawley |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | VERONIKA CHRISTI YOSANDA |
| Date Deposited: | 05 May 2026 03:33 |
| Last Modified: | 05 May 2026 03:33 |
| URI: | http://repository.upnvj.ac.id/id/eprint/41157 |
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