Olivia, . (2025) UJI EFEKTIVITAS EKSTRAK DAUN UBI JALAR UNGU (Ipomoea batatas L) TERHADAP HISTOPATOLOGI ARTERI KORONER TIKUS GALUR WISTAR (Rattus norvegicus) DIABETES. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Diabetes mellitus induces dyslipidemia which causes atherosclerosis and coronary heart disease the highest cause of death in the world. The use of purple sweet potato leaf extract (PSPLE) as a supportive therapy can inhibit atherosclerosis. The presence of flavonoids, saponins, and phenolic compounds as antioxidants, anti-inflammatory, hypolipidemic, and antihyperglycemic. This study aims to determine the effectiveness of PSPLE administration on the improvement of coronary artery histopathology in diabetic rats. Experimental research using postest only control group design method with a sample of 24 male white wistar strain rats, 2-3 months old, and body weight 150-200 grams. Rats were divided into 6 groups; normal control group (K1) given standard feed; negative control group (K2); positive control (K3); K4; K5; and K6 given high-fat feed for 14 days then induced alloxan 125 mg/kg, after 3 days of alloxan rats measured fasting blood glucose with a glucometer. Group K3 was given simvastatin 0.9 mg/kg. Group K4, K5, and K6 were given PSPLE doses of 150 mg/kg, 30 mg/kg, and 600 mg/kg for 18 days. The Kruskal Wallis test showed that the administration of PSPLE doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg had a significant effect (p<0.05) on the improvement of coronary artery histopathology in diabetic Wistar rats. The Mann-Whitney test showed that the administration of 600 mg/kg BB dose of extract was similar to the normal control group and simvastatin (p>0.05).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. PanggiL: 2110211131] [Pembimbing 1: Kristina Simanjuntak] [Pembimbing 2: Taufik Fredrik Pasiak] [Penguji: Cut Fauziah] |
| Uncontrolled Keywords: | Antioxidant, Atherosclerosis, Diabetes Mellitus, Purple Sweet Potato Leaf Extract, Coronary Artery Histopathology. |
| Subjects: | Q Science > QD Chemistry R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | OLIVIA |
| Date Deposited: | 13 Mar 2025 02:23 |
| Last Modified: | 13 Mar 2025 02:23 |
| URI: | http://repository.upnvj.ac.id/id/eprint/34234 |
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