Syarifah Nazira, . (2020) Uji Efektivitas Ekstrak Biji Ketumbar (Coriandrum sativum L.) Terhadap Gambaran Histopatologi Ginjal Tikus Model Hiperkolesterolemia Diabetes. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
![[img]](http://repository.upnvj.ac.id/style/images/fileicons/text.png) |
Text
ABSTRAK.pdf Download (1MB) |
|
Text
AWAL.pdf Download (5MB) |
|
Text
BAB I.pdf Download (2MB) |
|
Text
BAB II.pdf Download (9MB) |
|
Text
BAB III.pdf Download (5MB) |
|
Text
BAB IV.pdf Download (9MB) |
|
Text
BAB V.pdf Download (503kB) |
|
Text
DAFTAR PUSTAKA.pdf Download (3MB) |
|
Text
DAFTAR RIWAYAT HIDUP.pdf Download (575kB) |
|
Text
LAMPIRAN.pdf Download (4MB) |
|
Text
ARTIKEL.pdf Download (293kB) |
Abstract
Persistent hyperglicemia can trigger the production of oxidative stress. Oxidative stress can cause glomerular hypertrophy. Coriander seed extract has the potential to overcome oxidative stress. This study aims to determine the effect of coriander seed extract to kidney histopathological examination in hypercholestrolemia diabetic rats. Sample consist of 30 males wistar rats were divided into five treatments i.e: (K1) standard feed and aquades, (K2) high-fat feed, alloxan, and glibenclamid 0,045 mg/day, (K3) high-fat feed, alloxan, and coriander seed extract 300 mg/kgBW/day, (K4) high-fat feed, alloxan, and coriander seed extract 500mg/kgBW/day, (K5) high-fat feed, alloxan, and coriander seed extract 700mg/kgBW/day. Coriander seed extract was given for 28 days. The result of Wilcoxon test showed that coriander seed extract can reduce blood cholesterol level in diabetic hypercholesterolemia, meanwhile the result of paired T-test showed that it can reduce blood sugar level. Measurement of kidney’s histopathological structure as glomerular area was analyzed by Kruskal Wallis test (p=0,001) and continued with Mann-Whitney test. Group K4 can reduce glomerular area significantly compared with group K3 and K5. In conclussion, coriander seed extract can reduce blood cholesterol, blood sugar level and effectively reduce glomerular hypertrophy at dose of 500mg/kgBW/day. Keywords: Coriandrum sativum L., coriander seed extract, glomerular hypertrophy.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [Syarifah Nazira 1610211050] [Pembimbing : Maria Selvester Thadeus] [Penguji 1 : Niniek Hardini] |
| Uncontrolled Keywords: | Coriandrum sativum L., coriander seed extract, glomerular hypertrophy |
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Syarifah Nazira |
| Date Deposited: | 16 Sep 2022 04:03 |
| Last Modified: | 16 Sep 2022 04:03 |
| URI: | http://repository.upnvj.ac.id/id/eprint/7611 |
Actions (login required)
 |
View Item |