Syifa Aulia Muliadi, . (2026) PENGARUH PEMBERIAN EKSTRAK BUAH KELOR (Moringa oleifera fruits) TERHADAP KADAR TUMOR NECROSIS FACTOR α TIKUS Sprague-Dawley (Rattus norvegicus) MODEL OBESITAS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Objective: Obesity is recognized as a chronic low-grade inflammatory condition characterized by increased levels of Tumor Necrosis Factor-α (TNF-α). This proinflammatory cytokine plays a role in insulin resistance and metabolic diseases. Moringa oleifera fruit extract is rich in bioactive anti-inflammatory compounds that are presumed to suppress TNF-α levels. This study aimed to evaluate the effect of Moringa oleifera fruit extract on TNF-α levels in Sprague–Dawley rats with experimentally induced chronic obesity. Methods: This study employed a true experimental design with a post-test only control group approach. Obesity was induced in 30 male rats through a high-fat diet for 49 days. The treatment groups consisted of a normal control, negative control, positive control, and groups receiving Moringa oleifera fruit extract at a dose of 500 mg/kg body weight with varying administration frequencies (once and twice daily). After a two-week intervention period, TNF-α levels were measured using the ELISA method. Results: ANOVA analysis showed a significant difference among groups (p<0.001). Post hoc Tukey analysis revealed a significant difference between treatment group 1 and treatment group 2 (p<0.001), with a significant reduction in TNF-α levels in the treatment groups compared with the negative and positive control groups. No significant difference was observed between once-daily and twice-daily administration (p>0.05). However, TNF-α levels in the treatment groups were lower than those in the vitamin C group. Conclusion: It can be concluded that Moringa oleifera fruit extract is effective in reducing TNF-α levels. Since no significant difference was found between once-daily and twice-daily administration (p>0.05), once-daily administration is considered an effective dose for reducing TNF-α levels.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil : 2210211154] [Pembimbing 1 : Maria Selvester Thadeus] [Pembimbing 2 : Marlina Dewiastuti] [Penguji : Retno Yulianti] |
| Uncontrolled Keywords: | anti-inflammatory, Moringa oleifera fruits, Obesity, TNF- |
| Subjects: | R Medicine > RB Pathology R Medicine > RC Internal medicine |
| Divisions: | Fakultas Kedokteran |
| Depositing User: | SYIFA AULIA MULIADI |
| Date Deposited: | 25 Aug 2026 09:10 |
| Last Modified: | 01 Sep 2026 08:33 |
| URI: | http://repository.upnvj.ac.id/id/eprint/50240 |
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