EFEK PEMBERIAN EKSTRAK BUNGA KRISAN (Chrysanthemum morifolium) TERHADAP PROFIL KADAR GULA DARAH PADA TIKUS PUTIH (Rattus norvegicus) MODEL HIPERKOLESTEROLEMIA DIABETES

Walindah Diva Aureliya Tapi Tapi, Diva (2026) EFEK PEMBERIAN EKSTRAK BUNGA KRISAN (Chrysanthemum morifolium) TERHADAP PROFIL KADAR GULA DARAH PADA TIKUS PUTIH (Rattus norvegicus) MODEL HIPERKOLESTEROLEMIA DIABETES. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Diabetes mellitus is a chronic metabolic disorder caused by impaired insulin secretion and action, often accompanied by hypercholesterolemia. Chrysanthemum morifolium contains bioactive compounds with potential antihyperglycemic and antihypercholesterolemic effects. This study aimed to evaluate the effect of ethanol extract of chrysanthemum flowers on fasting blood glucose and cholesterol levels in male Wistar rats with a hypercholesterolemia–diabetes model. Methods This experimental study employed a pre-test and post-test control group design. Thirty male Wistar rats were divided into six groups: normal control, negative control, positive control (metformin 500 mg/kg body weight), and three treatment groups receiving ethanol extract of chrysanthemum flowers at doses of 75, 150, and 300 mg/kg body weight. The extract was obtained using the Ultrasound-Assisted Extraction (UAE) method with 96% ethanol and administered orally for 14 days. Fasting blood glucose and total cholesterol levels were measured before and after treatment. Data were analyzed using the Kruskal–Wallis test followed by the Mann–Whitney post hoc test with a significance level of p < 0.05. Results The ethanol extract of chrysanthemum flowers significantly reduced fasting blood glucose and cholesterol levels compared to the negative control group (p < 0.05). The greatest reductions were observed at a dose of 300 mg/kg body weight, with fasting blood glucose of 92.50 ± 2.08 mg/dL and cholesterol of 23.75 ± 1.50 mg/dL. No significant difference was found between the metformin group and the 300 mg/kg body weight extract group (p = 0 .050). Conclusion Ethanol extract of Chrysanthemum morifolium exhibits significant antihyperglycemic and antihypercholesterolemic effects in male Wistar rats with a hypercholesterolemia–diabetes model. These effects are dose-dependent, with the 300 mg/kg body weight dose being the most effective and comparable to metformin. Keywords: Chrysanthemum mori

Item Type: Thesis (Skripsi)
Additional Information: No. Panggil : 2210211159 Pembimbing 1 : dr. Retno Yulianti, M.Biomed Pembimbing 2 : dr. Maulidya Ayudika Dandanah, Sp.BTKV(K), FIHA Dosen Penguji : dr. Niniek Hardini, Sp.PA
Uncontrolled Keywords: Chrysanthemum morifolium, diabetes mellitus, hypercholesterolemia, Ultrasound-Assisted Extraction, Wistar rats
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: WALINDAH DIVA AURELIYA TAPI TAPI
Date Deposited: 05 May 2026 04:22
Last Modified: 05 May 2026 04:22
URI: http://repository.upnvj.ac.id/id/eprint/42388

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