Nabila Yasmin Surya Ananda, . (2026) PENGARUH PEMBERIAN EKSTRAK BUAH KELOR (MORINGA OLEIFERA FRUITS) TERHADAP KADAR ENZIM KATALASE HEPAR TIKUS (RATTUS NORVEGICUS) GALUR SPRAGUE DAWLEY MODEL OBESITAS. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
![[img]](http://repository.upnvj.ac.id/style/images/fileicons/text.png) |
Text
ABSTRAK.pdf Download (212kB) |
|
Text
AWAL.pdf Download (750kB) |
|
Text
BAB 1.pdf Restricted to Repository UPNVJ Only Download (478kB) |
|
Text
BAB 2.pdf Restricted to Repository UPNVJ Only Download (603kB) |
|
Text
BAB 3.pdf Restricted to Repository UPNVJ Only Download (403kB) |
|
Text
BAB 4.pdf Restricted to Repository UPNVJ Only Download (332kB) |
|
Text
BAB 5.pdf Download (224kB) |
|
Text
DAFTAR PUSTAKA.pdf Download (262kB) |
|
Text
RIWAYAT HIDUP.pdf Restricted to Repository UPNVJ Only Download (110kB) |
|
Text
LAMPIRAN.pdf Restricted to Repository UPNVJ Only Download (601kB) |
|
Text
HASIL PLAGIARISME.pdf Restricted to Repository staff only Download (10MB) |
|
Text
ARTIKEL KI.pdf Restricted to Repository staff only Download (509kB) |
Abstract
Introduction Obesity is a major risk factor for Non-Alcoholic Fatty Liver Disease (NAFLD), characterized by increased oxidative stress. Moringa fruit (Moringa oleifera fruits) is rich in antioxidants such as flavonoids, which may enhance endogenous antioxidant defenses, including the catalase enzyme. Objective This study aims to determine the effect of Moringa fruit extract on hepatic catalase enzyme concentration in obese rat models. Method A true experimental study with a post-test only control group design used 30 male Sprague Dawley rats. Obesity was induced using a high-fat diet for 49 days. Rats were divided into five groups: normal control (K1), negative control (K2), positive control (K3: obesity + vitamin C 15 mg/kgBW/day), treatment 1 (K4: obesity + Moringa fruit extract 500 mg/kgBW once daily), and treatment 2 (K5: obesity + Moringa fruit extract 500 mg/kgBW twice daily). Treatment was administered for 14 days. Hepatic catalase concentration was measured using a UV spectrophotometer at a wavelength of 240 nm. Data were analyzed using One Way ANOVA and Post Hoc Tukey tests. Result The highest hepatic catalase concentration was found in the negative control group (K2: 0.353 ng/mL), followed by K4 (0.206 ng/mL), K5 (0.175 ng/mL), K1 (0.144 ng/mL), and the lowest in K3 (0.116 ng/mL). Statistical analysis showed significant differences between groups (p<0.05). Moringa fruit extract at 500 mg/kgBW (once or twice daily) significantly reduced hepatic catalase concentration compared to the negative control (p<0.05). There was no significant difference between treatment groups 1 and 2 (p>0.05). Vitamin C was more effective in reducing catalase concentration than Moringa fruit extract. Conclusion Moringa fruit extract influences the reduction of hepatic catalase concentration in obese rats, suggesting its potential role in mitigating oxidative stress. Its effectiveness is comparable between once-daily and twice-daily administration, although vitamin C demonstrated a stronger effect. Keywords Catalase Enzyme, Moringa oleifera fruits, NAFLD, Obesity, Oxidative Stress, Sprague Dawley Rats.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2210211034] [Pembimbing 1: Maria Selvester Thadeus] [Pembimbing 2: Soroy Lardo] [Penguji: Niniek Hardini] |
| Uncontrolled Keywords: | Catalase Enzyme, Moringa oleifera fruits, NAFLD, Obesity, Oxidative Stress, Sprague Dawley Rats. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | NABILA YASMIN SURYA ANANDA |
| Date Deposited: | 01 May 2026 06:58 |
| Last Modified: | 01 May 2026 07:11 |
| URI: | http://repository.upnvj.ac.id/id/eprint/41541 |
Actions (login required)
 |
View Item |