Kenira Khairani Firdaus, . (2025) AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE INFUSA DAN KOMBUCHA KAYU SECANG (Caesalpinia sappan L.) SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose levels due to disturbances in insulin release, the body's response to insulin, or both. One commonly suggested therapeutic approach is the use of alpha-glucosidase enzyme inhibitors. This enzyme plays a role in the process of carbohydrate breakdown into glucose at the surface of the small intestine. Sappan wood has been empirically utilized for the treatment of diabetes mellitus. This study aims to analyze the % inhibition and IC50 value of alpha-glucosidase enzyme from secang wood infusa and secang wood kombucha in vitro. Alpha-glucosidase enzyme inhibition testing was carried out by determining enzyme activity at a wavelength of 410 nm. using an enzymatic microplate reader. The % inhibition value of secang wood infusa was 27.806% and secang wood kombucha was 86.654% with an IC50 value of 28.28%. The alpha-glucosidase inhibitory activity of secang wood kombucha is better than secang wood infusa. Analysis of differences in enzyme inhibitory activity between the two samples was carried out using the Kruskal-Wallis test, then followed by the Kruskal-Wallis One-Way ANOVA post hoc test, the results showed significant differences (p < 0.05).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 2110212052] [Pembimbing: Dhigna Luthfiyani Citra Pradana] [Penguji 1: Eldiza Puji Rahmi] [Penguji 2: Annisa Farida Muti] |
| Uncontrolled Keywords: | Alpha-Glucosidase Enzyme, Diabetes Mellitus, IC50, Secang Wood Kombucha, % Inhibition |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | KENIRA KHAIRANI FIRDAUS |
| Date Deposited: | 23 Jul 2025 04:53 |
| Last Modified: | 12 Aug 2025 03:56 |
| URI: | http://repository.upnvj.ac.id/id/eprint/38187 |
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