FORMULASI DAN STABILITAS PATCH TRANSDERMAL EKSTRAK ETANOL DAUN TEH (CAMELLIA SINENSIS) DENGAN VARIASI KONSENTRASI POLIMER HPMC DAN ETIL SELULOSA

Nabilla Zahrah Rahmawati, . (2025) FORMULASI DAN STABILITAS PATCH TRANSDERMAL EKSTRAK ETANOL DAUN TEH (CAMELLIA SINENSIS) DENGAN VARIASI KONSENTRASI POLIMER HPMC DAN ETIL SELULOSA. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Transdermal patches are currently in great demand because they can control drug release and cover inflammatory acne. However, the use of hydrophilic or hydrophobic homopolymers produces physical properties that do not meet existing criteria. This study aims to develop a transdermal patch formulation by combining two types of polymers to improve the properties and stability of the formulation in terms of physical and chemical properties. The method used was to conduct an accelerated stability test for 3 months on the formulation prepared at a temperature of 40°C and a relative humidity of 75%. The parameters observed included physical parameters (sensitivity, uniformity, thickness, water absorption, and folding resistance) and chemical parameters (pH and catechin concentration). As a result, the catechin content of the formulation was lower than the pure extract (67.8957 mg/g), which may be due to the formulation process. Formulation F1 (1% HPMC and 2% ethyl cellulose) showed the least decrease in physical and chemical stability. Based on statistical test results, the parameters of thickness, water content, pH, and catechin content had a p-value > 0.05. This indicates that the preparation is stable during three months of storage. Keywords: Tea leaves, Transdermal Patch, HPMC, Ethyl cellulose, Accelerated stability

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2110212009] [Pembimbing:Rika Revina] [Penguji 1:Aulia Farkhani] [Penguji 2:Via Rifkia]
Uncontrolled Keywords: Tea leaves, Transdermal Patch, HPMC, Ethyl cellulose, Accelerated stability
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Kedokteran > Program Studi Farmasi (S1)
Depositing User: NABILLA ZAHRAH RAHMAWATI
Date Deposited: 06 Aug 2025 06:34
Last Modified: 06 Aug 2025 06:34
URI: http://repository.upnvj.ac.id/id/eprint/38177

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