Amelia Luthfiyah Mulyadewi, . (2024) EFEK PEMBERIAN KEFIR SUSU KAMBING MADU PADA GAMBARAN HISTOPATOLOGI PANKREAS DAN FUNGSI GINJAL PADA TIKUS DIABETES. Amerta Nutrition, 8 (3SP). pp. 412-421. ISSN 2580-9776
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Abstract
Background: The prevalence of diabetes is rising. Chronic metabolic disease type 2 diabetes may damage renal function and harm the pancreas. One of the initiatives to prevent and manage type 2 diabetes through functional foods. The antidiabetic and antioxidant properties of goat milk kefir with honey are thought to help heal kidney and pancreatic damage. Objectives: Evaluating the effects of feading fermented goat milk with honey on pancreatic histopathology and renal function in diabetic rats. Methods: A true experimental study conducted on 42 male Sprague-Dawley rats aged 6-8 weeks were divided into Six groups: Healthy Rats(KS); DM Rats(KN); quercetin(K1); metformin(K2); Kefir(P1); Preventive(P2). Diabetic rats type 2 were conditioned by HFD and injecting streptozotocin. Oral kefir was given 1.8 ml/200g BW/day for 21 days to groups P1 and P2. Renal function was analyzed with pre-post tests through measurement of serum levels urea and creatinine, while the histopathological features were evaluated at the end of the study. The Kruskal-Wallis and post hoc Mann-Whitney test are used to analyze the data. Results: P1 rats had Creatinine level of 0.57 ± 0.07 mg/dL; BUN 27.56 ± 6.22 mg/dL; Islets of Langerhans 104.2; Island Area of Langerhans 170.26. The levels of BUN (p=0.830), creatinine (p=0.016), and Langerhans island area (p=0.026). Creatinine of rat P1 were significantly different from KN (p<0.05). Conclusions: Goat milk kefir with honey in type 2 diabetic rats show beneficial effects on serum BUN, creatinine, and histopathological features of the pancreas as treated with metformin
| Item Type: | Article |
|---|---|
| Additional Information: | [No.Panggil: 2110714089] [Pembimbing 1 : Ibnu Malkan Bakhrul Ilmi] [Pembimbing 2: Angga Hardiansyah] [Penguji 1: Nanang Nasrulloh] |
| Uncontrolled Keywords: | Diabetic, Kefir, Honey, Renal, Pancreas |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology |
| Divisions: | Fakultas Ilmu Kesehatan > Program Studi Gizi (S1) |
| Depositing User: | AMELIA LUTHFIYAH MULYADEWI |
| Date Deposited: | 05 Aug 2025 07:52 |
| Last Modified: | 05 Aug 2025 07:52 |
| URI: | http://repository.upnvj.ac.id/id/eprint/37863 |
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