THE EFFECTIVENESS OF FIBRAUREA TINCTORIA AS ANTICANCER PROPERTIES : A LITERATURE REVIEW

Nabila Fatihah Raihana, . (2025) THE EFFECTIVENESS OF FIBRAUREA TINCTORIA AS ANTICANCER PROPERTIES : A LITERATURE REVIEW. The effectiveness of Fibraurea tinctoria as anticancer properties: A literature review, 6 (1). pp. 229-245. ISSN 2721-558X

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Abstract

Background: Cancer remains a leading cause of mortality globally, necessitating exploration of natural compounds for therapeutic interventions. Fibraurea tinctoria Lour (FT), an indigenous herb in Asia, has shown potential anticancer properties, but its efficacy and mechanisms require further elucidation. Objectives: This review aims to summarize the existing literature on FT's anticancer effects of FT, focusing on its bioactive components, mechanisms of action, and the quantitative impact of FT extracts on various cancer cell lines. Methods: A systematic literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria across databases including Google Scholar, PubMed, and ScienceDirect, yielding six eligible studies from an initial pool of 321. These studies assessed both in vitro and in vivo effects, differing in the extract type, dosage, and treatment duration. Results: FT extracts exhibited notable antitumor effects, with palmatine hydrochloride (PaH) demonstrating significant inhibitory activity against cancer cell proliferation. Quantitative data indicated that FT extracts can reduce cancer cell viability by 28-82.79%, with PaH-PDT emerging as a promising therapeutic strategy, effectively inducing apoptosis in multiple cancer cell lines. Conclusion: FT extracts possess substantial anticancer potential primarily through mechanisms involving DNA damage and apoptosis induction.

Item Type:	Article
Additional Information:	[No.Panggil : 2110714086] [Pembimbing : A’immatul Fauziyah] [Penguji 1 : Muhammad Nur Hasan Syah]
Uncontrolled Keywords:	cancer, Fibraurea tinctoria, Palmatine hydrochloride, anticancer agents
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RZ Other systems of medicine
Divisions:	Fakultas Ilmu Kesehatan > Program Studi Gizi (S1)
Depositing User:	NABILA FATIHAH RAIHANA
Date Deposited:	05 Aug 2025 07:47
Last Modified:	05 Aug 2025 07:47
URI:	http://repository.upnvj.ac.id/id/eprint/37853

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