DAMPAK SERAT TERHADAP PRODUKSI ASAM LEMAK RANTAI PENDEK PADA PENDERITA PENYAKIT CROHN

Nabila Noor Aisah, . (2024) DAMPAK SERAT TERHADAP PRODUKSI ASAM LEMAK RANTAI PENDEK PADA PENDERITA PENYAKIT CROHN. DAMPAK SERAT TERHADAP PRODUKSI ASAM LEMAK RANTAI PENDEK PADA PENDERITA PENYAKIT CROHN, 5 (3b). pp. 1102-1112. ISSN 2714-6464

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Abstract

Crohn's disease patients experience dysbiosis or an imbalance in the composition of microbes in the gut, in contrast to individuals who do not have Crohn's disease. The intestinal immune system has a very important role in Crohn's disease. Pathogenesis can be understood from the immune system by knowing the gut microbiota. Short-chain fatty acids are anti-inflammatory substances produced from the breakdown of soluble fiber in the intestines by certain microbiota species. The purpose of this literature is to determine the effect of fiber on short-chain fatty acids and to form the gut microbiota of humans with Crohn's disease. A Systematic literature searches were conducted on Google Scholar, PubMed, Science Direct and Scopus. This review includes randomized controlled trials (RCTs) evaluating the role of fibre were sought between 2020-2024 to determine the application of fibre therapies and interventions to patients with Crohm's disease (age is not restricted). This literature study revealed that fiber may affect the composition of gut microbiota diversity in patients with Crohn's disease. Fiber increases the gut microbiota and produces short-chain fatty acids, especially increasing Firmicutes, Bifidobacteria, and Roseburia bacteria in Crohn's disease patients. In intestinal cells, short-chain fatty acids undergo cell proliferation, cell differentiation and gene expression. Short-chain fatty acids function as ligands that pair with G-proteins (GPCRs), including GPR41, GPR43 so that they activate the anti-inflammatory signal cascade. A wide variety of fermented fibers are able to produce the diversity of the intestinal microbiota of Crohn's disease patients and produce short-chain fatty acid molecules that can activate anti-inflammatory signals. Therefore, fiber as a prebiotic is very beneficial in maintaining the intestinal immune system in Crohn's disease patients.

Item Type:	Article
Additional Information:	[No.Panggil: 2110714018] [Pembimbing: Yessi Crosita Octaria] [Penguji 1: A'immatul Fauziyah]
Uncontrolled Keywords:	Crohn's disease, dietary fiber, fiber
Subjects:	Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General)
Divisions:	Fakultas Ilmu Kesehatan > Program Studi Gizi (S1)
Depositing User:	NABILA NOOR AISAH
Date Deposited:	05 Aug 2025 07:40
Last Modified:	05 Aug 2025 07:40
URI:	http://repository.upnvj.ac.id/id/eprint/37778

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