Hefrilia Hafishah, . (2025) UJI TOKSISITAS AKUT IN VITRO EKSTRAK DAUN DAN BUAH PARIJOTO (Medinilla speciosa Blume) DENGAN BRINE SHRIMP LETHALITY TEST (BSLT). Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Parijoto (Medinilla speciosa Blume) is a plant that thrives in highland areas and is commonly found in the Kudus region of Central Java, where it is widely utilized as a medicinal plant. In the development of natural-based drugs, laboratory testing is essential to ensure both efficacy and safety. This study aims to determine the toxicity levels of leaf and fruit extracts of parijoto, obtained through Ultrasonic-Assisted Extraction (UAE), using 48-hour-old Artemia franciscana larvae in a Brine Shrimp Lethality Test (BSLT). The results of the total phenolic content analyses indicate that the leaf extract of parijoto contains higher levels of these compounds (87,8989 mgGAE/g extract) compared to the fruit extract (46,3708 mgGAE/g extract; p ≤ 0,05). The range of toxic concentrations of parijoto leaf and fruit extracts obtained from preliminary tests followed by definitive tests resulted in Lethal Concentration 50 (LC50) values of 57.822 ± 6.578 ppm and 72.662 ± 5.690 ppm, respectively, both of which fall into the toxic category according to Mayer's classification and are classified as highly toxic according to Clarkson's classification.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2110212007] [Pembimbing: Annisa Farida Muti] [Penguji 1: Eldiza Puji Rahmi] [Penguji 2: Dhigna Luthfiyani Citra Pradana] |
| Uncontrolled Keywords: | Artemia franciscana, BSLT, LC50, Parijoto, Toxicity |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | HEFRILIA HAFISHAH |
| Date Deposited: | 05 Aug 2025 07:10 |
| Last Modified: | 05 Aug 2025 07:10 |
| URI: | http://repository.upnvj.ac.id/id/eprint/37324 |
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