PERBANDINGAN EFEKTIVITAS ANTIJAMUR EKSTRAK DAUN UNGU (Graptophillum Pictum L. Griff) DAN ISOLAT Actinomycetes DENGAN MENGGUNAKAN METODE ULTRASOUND-ASSISTED EXTRACTION (UAE) TERHADAP PERTUMBUHAN Candida albicans

Desya Rizqia Putri Khairani, . (2025) PERBANDINGAN EFEKTIVITAS ANTIJAMUR EKSTRAK DAUN UNGU (Graptophillum Pictum L. Griff) DAN ISOLAT Actinomycetes DENGAN MENGGUNAKAN METODE ULTRASOUND-ASSISTED EXTRACTION (UAE) TERHADAP PERTUMBUHAN Candida albicans. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Candida albicans is an opportunistic fungus that causes infections that still has a high prevalence rate. The use of synthetic drugs can cause side effects and increased resistance, so the search for safer and more effective antifungal alternatives is crucial. This study aims to determine the comparison of the antifungal effectiveness of Purple Leaf Extract (Graptophyllum pictum (L.) Griff) and Actinomycetes Isolate using the Ultrasound-Assisted Extraction (UAE) method on the growth of C. albicans. This study uses 3 concentrations, namely 30;, 40%; and 50% which will then be tested by the well diffusion method. Purple Leaf Extract at concentrations of 30%, 40%, and 50% was able to inhibit the growth of C. albicans with an average diameter of 18.2 mm of inhibition zones, 17.25 mm; and 16,475 mm respectively. Meanwhile, Actinomycetes isolates at concentrations of 30%; 40%; and 50% were able to inhibit C. albicans with an average inhibition zone diameter of 12.05 mm; 11,425 mm; and 10,875 mm , respectively. Independent tests of T-test and Mann-whitney showed that there was a significant difference in the inhibition zone in each consentration group between Purple Leaf extract and Actinomycetes isolate against the growth of Candida albicans in each concentration. The compounds contained in purple leaves and Actinomycetes isolates both work by binding to ergosterol to form complex compounds that then increase the permeability of cell membranes. The treatment group of Purple Leaf Extract produced a larger inhibition zone, especially at a concentration of 30% with an average inhibition zone of 18.2 mm.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2110211122] [Pembimbing 1: Meiskha Bahar] [Pembimbing 2: Yuni Setyaningsih] [Penguji: Fajriati Zulfa]
Uncontrolled Keywords: Actinomycetes, Antifungal, Candida albicans, Purple leaf, Ultrasound-Assisted Extraction (UAE)
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: DESYA RIZQIA PUTRI KHAIRANI
Date Deposited: 25 Mar 2025 01:51
Last Modified: 25 Mar 2025 01:51
URI: http://repository.upnvj.ac.id/id/eprint/36546

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