Tri Irawati, . (2024) LITERATURE REVIEW: PERAN VITAMIN D TERHADAP INFLAMASI PADA KEJADIAN SINDROM OVARIUM POLIKISTIK (SOPK). Jurnal Sago Gizi dan Kesehatan, 5 (3B). pp. 846-856. ISSN 2721-558X
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Abstract
Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 5-18% of women of reproductive age, with a high prevalence in Europe and 1,8-15% in Indonesia. PCOS is often associated with chronic inflammation and vitamin D deficiency, which can exacerbate symptoms and increase the risk of cardiovascular disease due to the anti-inflammatory effects of vitamin D. To determine the role and most effective dosage of vitamin D in reducing inflammatory markers through a literature review. The methodology employed is a Systematic Literature Review using the PRISMA method. A search in the Google Scholar, ScienceDirect, and Scopus databases yielded 1,046 articles, of which 7 RCT articles were selected for analysis. The selected articles investigate the effects of vitamin D on inflammation in PCOS, with a total population of 434 participants, published between 2019 and 2024, and were deemed suitable using The Joanna Briggs Institute (JBI) Critical Appraisal method. Out of seven randomized controlled trials (RCTs), five showed that vitamin D supplementation reduced levels of inflammatory biomarkers such as hs-CRP in patients with PCOS. Results varied depending on the dosage, but two specific dosages of vitamin D supplementation 4,000 IU and 50,000 IU showed potential as adjunctive therapy for managing PCOS. Vitamin D supplementation is effective in reducing inflammation in PCOS and has potential as a beneficial adjunctive therapy with positive implications for the long-term health of patients. Dosages of 4,000 IU per day and 50,000 IU every two weeks have been proven effective in reducing PCOS-related inflammation. However, due to the limited number of studies reviewed, the most effective combination of micronutrients to be used alongside vitamin D has yet to be determined.
| Item Type: | Article |
|---|---|
| Additional Information: | [No.Panggil: 2110714003] [Pembimbing: Yessi Crosita Octaria] [Penguji: Avliya Quratul Marjan] |
| Uncontrolled Keywords: | Inflammation, Polycystic Ovary Syndrome, vitamin D |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Ilmu Kesehatan > Program Studi Gizi (S1) |
| Depositing User: | TRI IRAWATI |
| Date Deposited: | 05 Aug 2025 07:32 |
| Last Modified: | 05 Aug 2025 07:32 |
| URI: | http://repository.upnvj.ac.id/id/eprint/36492 |
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