Adzra Annisa, . (2024) Efektivitas Pemberian Obat Antihipertensi Tunggal dan Kombinasi pada Pasien Hipertensi dengan Gagal Ginjal Kronis di RSUD Kota Bogor. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Objective: Hypertension is one of the most non-communicable diseases in Indonesia. Hypertension can cause various cardiovascular-related complication such as heart failure, coronary artery disease, thus chronic kidney disease. Based on their pathophysiology, hypertension causes a progressive decline in kidney function. Furthermore, decreased kidney function due to chronic kidney disease causes blood pressure control to worsen, so that hypertension and chronic kidney disease are fairly associated. Method: The research aimed to investigate the effectiveness of antihypertensive single and combination drugs in hypertension with chronic kidney disease patients at RSUD Kota Bogor. This study is an observational study with cross-sectional design, with total of 87 samples taken using purposive sampling. Data were taken from hypertension with chronic kidney disease patients’ medical record in RSUD Kota Bogor from January to December 2023 then analyzed univariately and bivariately with Kruskal-Wallis test and post hoc Mann-Whitney test. Results: Univariate analysis shows 31.8% patients received single group of antihypertensive drugs, 39.3% received combination of 2 group, 22.5% received combination of 3 group, and 7.2% received combination of 4 group. Bivariate analysis shows there was a significant differences in diastolic blood pressure after receiving antihypertensive drugs (p-value = 0.023). Conclusion: The most effective antihypertensive drugs in hypertension with chronic kidney disease patients at RSUD Kota Bogor is combination of 3 group antihypertensive drugs, specifically combination of ACE inhibitor + calcium channel blocker + beta blocker and combination of angiotensin receptor blocker + beta blocker + alpha-2 adrenergic agonist.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2110211045] [Pembimbing: Hany Yusmaini] [Penguji 1: Yosha Putri Wahyuni] [Penguji 2: Erna Harfiani] |
| Uncontrolled Keywords: | hypertension, chronic kidney disease, single group antihypertensive drugs, combination group antihypertensive drugs. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | ADZRA ANNISA |
| Date Deposited: | 26 Mar 2025 02:18 |
| Last Modified: | 26 Mar 2025 02:18 |
| URI: | http://repository.upnvj.ac.id/id/eprint/34961 |
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