Dinda Tri Wulandari, . (2024) IDENTIFIKASI OBAT BERPOTENSI HEPATOTOKSIK PADA PASIEN SIROSIS HATI RAWAT INAP DI RSPAD GATOT SOEBROTO TAHUN 2023. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Liver cirrhosis is a condition of chronic liver damage characterized by the formation of fibrosis in the liver. Treatment of patients with liver cirrhosis and its complications requires careful consideration of therapy selection because there are drugs that induce hepatotoxicity. This research was conducted to identify potentially hepatotoxic drugs in inpatients with liver cirrhosis at the RSPAD Gatot Soebroto in 2023. This study used a cross-sectional observational method with a retrospective approach using medical records of patients with liver cirrhosis. Hepatotoxic drugs were identified using LiverTox. The research results showed that the majority of patients were male (67.7%), aged 19-59 years (59.7%), had a normal Body Mass Index (BMI) (58.1%), Child Pugh Score category C (17.7%), had high SGOT and SGPT before and after treatment, the highest pharmacological class in the patient's therapy profile was multivitamin/mineral/supplement/electrolyte fluid (34.0%), the highest use of potentially hepatotoxic drugs based on the Likelihood Score in the category X (31.4%), and the most common mechanism of hepatotoxicity was hypersensitivity or immunoallergic reaction (14.4%). The use of potentially hepatotoxic drugs in inpatient liver cirrhosis patients at the RSPAD Gatot Soebroto in 2023 is still relatively high, namely 595 prescriptions (61.27%).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2010212004] [Pembimbing 1: Annisa Farida Muti] [Pembimbing 2: Ima Maria] [Penguji Utama: Primayanti Nurul Ilmi] |
| Uncontrolled Keywords: | Hepatotoxic, Potential, LiverTox, Liver cirrhosis |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | DINDA TRI WULANDARI |
| Date Deposited: | 09 Sep 2024 02:49 |
| Last Modified: | 09 Sep 2024 02:49 |
| URI: | http://repository.upnvj.ac.id/id/eprint/32046 |
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