UJI INHIBISI ENZIM LIPASE EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) DENGAN METODE EKSTRAKSI ULTRASONIK SEBAGAI KANDIDAT ANTIOBESITAS SECARA IN VITRO

Zahra Fikriya, . (2024) UJI INHIBISI ENZIM LIPASE EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) DENGAN METODE EKSTRAKSI ULTRASONIK SEBAGAI KANDIDAT ANTIOBESITAS SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Obesity is characterized by excessive body weight due to a disproportion between energy intake and expenditure. Orlistat is the only anti-obesity drug that works by inhibiting the lipase enzyme, however, it has side effects such as gastrointestinal complications, necessitating safer alternative therapies. Kelor leaves (Moringa oleifera) have the potential as a lipase enzyme inhibitor due to its phytochemical content, including flavonoids, phenolics, alkaloids, saponins, and terpenoids. The leaves were extracted using 50% ethanol with ultrasonic extraction at varying frequencies of 30 kHz, 40 kHz, and 50 kHz. The total phenolic content in each extract was tested using the Folin-Ciocalteu reagent, while the total flavonoid content was tested with CH3COONa and AlCl3 reagents. Lipase enzyme inhibition was tested in vitro using visible spectrophotometry with the substrate p-Nitrophenyl Butyrate (p-NPB) and measured at 405 nm. Extracts at frequencies of 30 kHz, 40 kHz, and 50 kHz show lipase enzyme inhibition activity, with the highest inhibition of 54.1197% from the extract at 40 kHz frequency at a concentration of 12500 ppm. There are no significant differences in inhibition percentages among the three extraction frequencies (Sig>0.05).

Item Type: Thesis (Skripsi)
Additional Information: [No. Panggil: 2010212014] [Pembimbing 1: Annisa Farida Muti] [Pembimbing 2: Rika Revina] [Penguji: Eldiza Puji Rahmi]
Uncontrolled Keywords: Lipase Enzyme, Moringa oleifera Leaves, Obesity, Ultrasonic Extraction
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran > Program Studi Farmasi (S1)
Depositing User: ZAHRA FIKRIYA
Date Deposited: 06 Sep 2024 03:17
Last Modified: 06 Sep 2024 03:17
URI: http://repository.upnvj.ac.id/id/eprint/31726

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