PENGARUH EKSTRAK KULIT TERUNG UNGU (SOLANUM MELONGENA L.) TERHADAP KADAR KOLESTEROL TOTAL TIKUS GALUR WISTAR (RATTUS NORVEGICUS) DIABETES YANG DIINDUKSI ALOKSAN

Aulia NH. Bella Srikandi, . (2024) PENGARUH EKSTRAK KULIT TERUNG UNGU (SOLANUM MELONGENA L.) TERHADAP KADAR KOLESTEROL TOTAL TIKUS GALUR WISTAR (RATTUS NORVEGICUS) DIABETES YANG DIINDUKSI ALOKSAN. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Dyslipidemia in patients with diabetes mellitus causes atherosclerosis, triggering cardiovascular disease with the highest mortality rate in Indonesia. Alternative therapy with purple eggplant (Solanum melongena L.) peel, which contains flavonoids, acts as an HMG-CoA reductase inhibitor. The aim of this study was to determine the effect of purple eggplant peel extract (EKTU) on the total cholesterol levels of Wistar diabetic rats (Rattus norvegicus) induced with alloxan. The research design was a true experiment using a posttest-only control group design. Thirty Wistar rats, weighing 150-200 grams and aged 2-3 months, were randomly selected. The rats were fed a high-fat diet and divided into K1 (standard diet, distilled water), K2 (alloxan), K3 (alloxan, simvastatin), and K4, K5, K6 {alloxan, EKTU doses of 75, 150, and 300 (mg/kgBW)}, with a treatment period of 14 days. The rats were anesthetized with Ketamine Xylazine, blood was collected in EDTA tubes, and total cholesterol was examined using the CHOD-PAP method. The Kruskal-Wallis test results showed the influence of EKTU on the total cholesterol levels of Wistar diabetic rats (p=0.009). Post-Hoc Mann-Whitney test showed that the administration of EKTU at a dose of 150 mg/kgBW was almost the same as simvastatin (p=0.402). Purple eggplant peel extract can reduce the total cholesterol levels in Wistar diabetic rats.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2010211131] [Pembimbing 1: Kristina Simanjuntak] [Pembimbing 2: Cut Fauziah] [Penguji: Marlina Dewiastuti]
Uncontrolled Keywords: Purple Eggplant Peel Extract, Diabetes Mellitus, Alloxan, Total Cholesterol
Subjects: Q Science > Q Science (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Aulia NH Bella Srikandi
Date Deposited: 21 Jan 2024 01:27
Last Modified: 08 Mar 2024 07:59
URI: http://repository.upnvj.ac.id/id/eprint/27933

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