Dipo Fahrezza Fatah, . (2023) EFEKTIVITAS EKSTRAK KULIT TERUNG UNGU (Solanum melongena L.) TERHADAP KADAR LOW DENSITY LIPOPROTEIN (LDL) TIKUS GALUR WISTAR DIABETIK. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Dyslipidemia as a complication of diabetes mellitus triggers cardiovascular disturbances, which cause of highest mortality in the world. Purple eggplant (Solanum melongena L.) containing flavonoids, which act as HMG-CoA reductase inhibitors, can serve as a non-pharmacological therapy. This research aims to determine the effectiveness of administering purple eggplant skin extract (EKTU) on the levels of low-density lipoprotein (LDL) in diabetic Wistar rats. The research design was true experimental using post test only control group design. The research sample used 30 Wistar rats, 2-3 months old, and weighing 150-200 grams taken by simple random sampling from the University Padjadjaran Faculty of Medicine Laboratory. The rats were grouped into 6 groups with details; standard diet in K1 (distilled water) and high-fat diet in K2 (alloxan), K3 (alloxan, simvastatin), and K4, K5, K6 {alloxan, EKTU doses 75, 150, 300 (mg/kgBW)}, and received treatment for 14 days. The rats were anesthetized with Ketamine Xylazine injection, blood was stored in EDTA tubes, and LDL was examined by homogeneous enzymatic colorimetric test. The results of One-Way ANOVA test indicated an influence of purple eggplant skin extract administration on LDL levels in diabetic Wistar rats (p=0.005). The Post-Hoc Bonferroni test revealed that the administration of 75mg/kgBW purple eggplant skin extract approached the effects of simvastatin (p=1.000). Administering purple eggplant skin extract could reduce LDL levels in diabetic Wistar rats.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [NIM: 2010211055] [Pembimbing 1: Dra. Kristina Simanjuntak, M.Biomed] [Pembimbing 2: dr. Nugrahayu Widyawardani, M.Gizi, Sp.GK] [Penguji: Dra. Cut Fauziah, M.Biomed] |
| Uncontrolled Keywords: | Keywords: Purple Eggplant Skin Extract, Diabetes Mellitus, LDL |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Dipo Fahrezza Fatah |
| Date Deposited: | 05 Mar 2024 08:07 |
| Last Modified: | 05 Mar 2024 08:46 |
| URI: | http://repository.upnvj.ac.id/id/eprint/27931 |
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- EFEKTIVITAS EKSTRAK KULIT TERUNG UNGU (Solanum melongena L.) TERHADAP KADAR LOW DENSITY LIPOPROTEIN (LDL) TIKUS GALUR WISTAR DIABETIK. (deposited 05 Mar 2024 08:07) [Currently Displayed]
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