POTENSI EKSTRAK DAUN JATI BELANDA (Guazuma ulmifolia) TERHADAP PERBAIKAN HISTOPATOLOGI GINJAL DAN KADAR KREATININ TIKUS WISTAR DENGAN PAKAN TINGGI LEMAK

Raden Ayu Salsabila Rifdah, . (2023) POTENSI EKSTRAK DAUN JATI BELANDA (Guazuma ulmifolia) TERHADAP PERBAIKAN HISTOPATOLOGI GINJAL DAN KADAR KREATININ TIKUS WISTAR DENGAN PAKAN TINGGI LEMAK. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Obesity has been shown to be one of the important causes of kidney disease due to its close association with diabetes and hypertension. Obesity affects the progression of Chronic Kidney Disease (CKD) because it is one of the predisposing factors for diabetic nephropathy with histopathological features of Interstitial Inflammation and Interstitial Fibrosis and Tubular Atrophy (IFTA), in addition to arteriosclerosis and Arteriolar hyalinosis. Flavonoids and tannins are secondary metabolites present in West Indian Elm leaves (Guazuma ulmifolia) that have therapeutic effects on lowering serum creatinine and inhibiting the progressivity of IFTA and Interstitial Inflammation lesions. Through experimental research with renal histopathology parameters in the form of indicators of IFTA lesion progressivity and Interstitial Inflammation, 25 wistar rats were held and induced with high-fat diet, then divided into 5 groups consisting of 2 control groups and 3 treatment groups of West Indian Elm leaves extract at a dose of 0.2 gr/KgBB, 0.4 gr/KgBB, 0.8 gr/KgBB. By using the Kruskal-Wallis test and Mann Whitney Post-Hoc Test, the results obtained were significant (P Value <0.05). It can be concluded that West Indian Elm Leaves extract inhibits the progressivity of IFTA and Interstitial Inflammation lesions and has a therapeutic effect equivalent to orlistat if the dose given is adequate.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 1910211052] [Pembimbing 1: Maria Selvester Thadeus] [Pembimbing 2: Yanto Sandy Tjang] [Penguji 1: Yuni Setyaningsih]
Uncontrolled Keywords: West Indian Elm Leaves, Orlistat, Histopathology, IFTA, Interstitial Inflammation
Subjects: R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Raden Ayu Salsabila Rifdah
Date Deposited: 02 Mar 2023 04:26
Last Modified: 02 Mar 2023 04:26
URI: http://repository.upnvj.ac.id/id/eprint/23223

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