Mei Putra Daya, . (2019) EFEK ANTINOSISEPTIF FLAVONOID DAUN TANAMAN Leea indica TERHADAP NYERI OROFASIAL IKAN ZEBRA DEWASA (Danio rerio). Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Background. Pain occurs due to stimuli from pain receptors called nociceptors. One pain known in the medical world is orofacial pain, which is defined as pain that occurs in soft and hard tissue in the head, face and neck area. Research purposes. This study aims to determine the antinociceptive effect of flavonoids isolated from the Leea indica plant, on orofacial pain in zebrafish (Danio rerio), as a test model for behavior or locomotor activity. To study the orofacial pain of zebrafish induced with glutamate. Method. This research is a true experiment. The parameter used is the number of times the fish crossed the line between the caudran from the glass petri dish during 0-5 minutes and 15-30 minutes. Tramadol is used as a positive kontrol. Results. Anova one way test p-value 0.0001 shows that there are differences in lokomotor activity measured from 0-5 minutes and 15-30 minutes by giving flavonoids can affect zebra fish lokomotor activity or an increase in zebra fish lokomotor activity. Antinociceptive effects of flavonoids are similar to tramadol. Conclusion. Flavonoids from Leea indica have antinociceptive effects on orofacial pain in adult zebrafish (Danio rerio). The flavonoid dose 2.5 mg / ml is a dose that has a significant difference in all treatment groups.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No Panggil : 1610211060] [Pembimbing : Arman Yurisaldi] [Penguji : Riezky Valentina Astari] |
| Uncontrolled Keywords: | Leea indica, flavonoids, zebrafish |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Deny Wahyudin |
| Date Deposited: | 05 Jul 2022 06:42 |
| Last Modified: | 05 Jul 2022 06:42 |
| URI: | http://repository.upnvj.ac.id/id/eprint/18221 |
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