Soraya Maulidina, . (2022) EFEKTIVITAS PENGGUNAAN KORTIKOSTEROID TERHADAP PASIEN COVID-19 DERAJAT BERAT DENGAN ARDS: Tinjauan Sistematik. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Introduction: ARDS is a major complication of COVID-19 infection and is associated with a high mortality rate. Currently, no definitive therapy has been shown to reduce ARDS-related mortality with either COVID-19 or non-COVID-19 etiology. The mechanism COVID-19 progresses to ARDS is thought to be due to a cytokine storm. The anti-inflammatory effect of corticosteroids may reduce pulmonary and systemic hyperinflammation due to increased secretion of proinflammatory cytokines. This systematic review will review the effectiveness of using corticosteroids in severe COVID-19 patients with ARDS. Method: A systematic review was conducted by searching the literature on Pubmed and Google Scholar databases with reference to the PRISMA-P method. The literature obtained was then selected through the JBI Critical Appraisal Checklist. Results: administration of corticosteroids with low-high doses of IV methylprednisolone 0.6 – 8 mg/kg/day or high doses of IV dexamethasone 10 – 20 mg/day for 10 days during the early phase of ARDS or risk of developing ARDS (clinical worsening >7 days of onset symptoms) or >72 hours of hospitalization yielded beneficial outcomes in severe COVID-19 patients with ARDS. Corticosteroids were associated with a decreased blood CRP levels, improved ventilation and oxygenation, but did not reduced the risk of mortality and decrease the duration of hospitalization. Conclusion: the use of corticosteroids helps to provide beneficial outcomes in severe COVID-19 patients with ARDS
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 1810211017] [Pembimbing 1: Hany Yusmaini] [Pembimbing 2: Yanti Harjono Hadiwiardjo] [Penguji: Dhigna Luthfiyani C.P.] |
| Uncontrolled Keywords: | Corticosteroid, COVID-19, ARDS. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Soraya Maulidina |
| Date Deposited: | 22 Feb 2022 05:36 |
| Last Modified: | 22 Feb 2022 08:04 |
| URI: | http://repository.upnvj.ac.id/id/eprint/16420 |
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