Miranda Natalia Malau, . (2020) PENGARUH PEMBERIAN KORTIKOSTEROID DOSIS RENDAH TERHADAP HITUNG JENIS LEUKOSIT PADA SEPSIS TAHAP AWAL. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Early-stage sepsis is characterized by excessive activation of circulating leukocytes, increasing the number of leukocytes exceeding the normal value. Low-dose corticosteroids show significant effects in patients with early-stage sepsis. This study aims to analyze the effect of low-dose corticosteroids on leukocyte differential count of Balb/C mice in early-stage sepsis. This research type is a true experiment with a post-test only control group research design. The subjects in this study were 30 male Balb/C mice. The sample was randomly divided into 3 groups, which is the control group, the sepsis (cecal inoculum induction) group and the sepsis added with methylprednisolone 1,3 mg/day (equals to 50 mg/day in human) group. The results of the Post-Hoc Bonferroni test of the sepsis group against the control group showed significant differences in the differential count of neutrophils (p=0,009), monocytes (p=0,009) and lymphocytes (p=0,003). The results of the Post-Hoc Bonferroni test of the sepsis group against the sepsis added with low-dose corticosteroids group showed significant differences in the monocyte (p=0,009) and lymphocytes (p=0,046), while neutrophils showed no significant differences of differential count (p=0,100).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil: 1610211026] [Pembimbing: Erna Harfiani] [Penguji: Dhigna Luthfiyani Citra P] |
| Uncontrolled Keywords: | Cecal Inoculum, Leukocyte Differential Count, Low-dose Corticosteroids, Early-stage Sepsis |
| Subjects: | Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Miranda Natalia Malau |
| Date Deposited: | 16 Sep 2022 03:32 |
| Last Modified: | 16 Sep 2022 03:32 |
| URI: | http://repository.upnvj.ac.id/id/eprint/7731 |
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