AKTIVITAS PENGHAMBATAN EKSTRAK DAUN DANDANG GENDIS DAN PROBIOTIK (Lactobacillus acidophilus) TERHADAP PERTUMBUHAN BAKTERI GASTROINTESTINAL (Salmonella typhi dan Escherichia coli)

Nadia Elzuhria A, . (2026) AKTIVITAS PENGHAMBATAN EKSTRAK DAUN DANDANG GENDIS DAN PROBIOTIK (Lactobacillus acidophilus) TERHADAP PERTUMBUHAN BAKTERI GASTROINTESTINAL (Salmonella typhi dan Escherichia coli). Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

[img] Text
ABSTRAK.pdf
Download (366kB)
[img] Text
AWAL.pdf
Download (1MB)
[img] Text
BAB 1.pdf
Restricted to Repository UPNVJ Only
Download (341kB)
[img] Text
BAB 2.pdf
Restricted to Repository UPNVJ Only
Download (822kB)
[img] Text
BAB 3.pdf
Restricted to Repository UPNVJ Only
Download (557kB)
[img] Text
BAB 4.pdf
Restricted to Repository UPNVJ Only
Download (757kB)
[img] Text
BAB 5.pdf
Download (324kB)
[img] Text
DAFTAR PUSTAKA.pdf
Download (391kB)
[img] Text
RIWAYAT HIDUP.pdf
Restricted to Repository staff only
Download (224kB)
[img] Text
LAMPIRAN.pdf
Restricted to Repository UPNVJ Only
Download (1MB)
[img] Text
HASIL PLAGIARISME.pdf
Restricted to Repository staff only
Download (716kB)
[img] Text
ARTIKEL KI.pdf
Restricted to Repository staff only
Download (524kB)

Abstract

Gastrointestinal infections caused by Escherichia coli and Salmonella typhi remain a significant health problem, particularly due to the increasing incidence of antibiotic resistance. Clinacanthus nutans leaves have demonstrated antibacterial potential against Salmonella typhi and Escherichia coli, with phenolic and flavonoid compounds identified as key secondary metabolites. In addition, metabolites produced by Lactobacillus acidophilus have been reported to inhibit the growth of Salmonella and E. coli. This study aimed to evaluate the antibacterial activity of dandang gendis leaf extract (Clinacanthus nutans) and the probiotic Lactobacillus acidophilus, both individually and in combination, against gastrointestinal pathogenic bacteria. This in vitro study employed bacterial growth measurement based on optical density (OD₆₀₀), determination of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and inhibition zone assays. The results showed that dandang gendis leaf extract exhibited antibacterial activity against S. typhi, with an MIC value at a concentration of 50% (500 mg/mL), an MBC value at 200% (2000 mg/mL), a single-extract inhibition zone of 9,19 ± 0.604 mm, and a combination inhibition zone of 10,5 ± 0.98 mm. In contrast, no antibacterial activity against E. coli was observed in the MIC, MBC, or inhibition zone assays. The differences in inhibitory responses between E. coli and S. typhi are presumed to be associated with variations in membrane structure, porin characteristics, and efflux pump mechanisms.. This study indicates that the combination of dandang gendis leaf extract and L. acidophilus has potential as an alternative approach for inhibiting gastrointestinal pathogenic bacteria.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210212046] [Pembimbing: Eldiza Puji Rahmi] [Penguji 1: Andiri Niza Syarifah] [Penguji 2: Rika Revina]
Uncontrolled Keywords: Antibacterial, Clinacanthus nutans, Escherichia coli, Lactobacillus acidophilus, Salmonella typhi
Subjects: Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Fakultas Kedokteran > Program Studi Farmasi (S1)
Depositing User: NADIA ELZUHRIA A
Date Deposited: 28 Aug 2026 03:31
Last Modified: 28 Aug 2026 03:31
URI: http://repository.upnvj.ac.id/id/eprint/50804

Actions (login required)

View Item View Item