HISTOPATOLOGI PANKREAS SETELAH PEMBERIAN EKSTRAK BUNGA KRISAN (Chrysanthemum morifolium) PADA TIKUS PUTIH (Rattus norvegicus) MODEL HIPERKOLESTEROLEMIA-DIABETES

Theo Charisman Oktoberius Ndruru, . (2026) HISTOPATOLOGI PANKREAS SETELAH PEMBERIAN EKSTRAK BUNGA KRISAN (Chrysanthemum morifolium) PADA TIKUS PUTIH (Rattus norvegicus) MODEL HIPERKOLESTEROLEMIA-DIABETES. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Diabetes mellitus and hypercholesterolemia are metabolic disorders that can cause structural damage to the pancreas through mechanisms involving oxidative stress and chronic inflammation. Chrysanthemum flower extract (Chrysanthemum morifolium) contains bioactive compounds with potential protective effects on pancreatic beta cells; however, its impact on pancreatic histopathological changes under hypercholesterolemic–diabetic conditions remains limited. This study aimed to evaluate the histopathological features of the pancreas following administration of chrysanthemum flower extract in hypercholesterolemic–diabetic white rats (Rattus norvegicus). This study was an experimental study employing a post-test only control group design. Wistar rats were induced with hypercholesterolemia and diabetes using a high-fat diet and alloxan, then divided into control groups and treatment groups receiving chrysanthemum flower extract at doses of 75, 150, and 300 mg/kg body weight. Pancreatic histopathological examination was performed using Hematoxylin–Eosin staining, with assessment of necrotic cells and inflammatory cell indicators. Data were analyzed using the Kruskal–Wallis test followed by post hoc Mann–Whitney analysis. The results demonstrated that administration of chrysanthemum flower extract significantly reduced the number of pancreatic necrotic and inflammatory cells compared to the negative control group, with the most pronounced histopathological improvement observed at a dose of 300 mg/kg body weight. In conclusion, chrysanthemum flower extract has the potential to ameliorate pancreatic histopathological damage in a hypercholesterolemic–diabetic rat model.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210211017] [Pembimbing 1: Retno Yulianti] [Pembimbing 2: Meiskha Bahar] [Penguji: Maria Selvester Thadeus]
Uncontrolled Keywords: Chrysanthemum morifolium, diabetes mellitus, hypercholesterolemia, pancreatic histology, Wistar rats.
Subjects: R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: THEO CHARISMAN OKTOBERIUS NDRURU
Date Deposited: 04 May 2026 03:20
Last Modified: 04 May 2026 03:20
URI: http://repository.upnvj.ac.id/id/eprint/41884

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