PERBANDINGAN NILAI NATIONAL INSTITUTE OF HEALTH STROKE SCALE PASIEN STROKE ISKEMIK SEBELUM DAN SESUDAH TERAPI TROMBOLISIS DI RSUP FATMAWATI TAHUN 2024

Sharina Putri Widiyani, . (2026) PERBANDINGAN NILAI NATIONAL INSTITUTE OF HEALTH STROKE SCALE PASIEN STROKE ISKEMIK SEBELUM DAN SESUDAH TERAPI TROMBOLISIS DI RSUP FATMAWATI TAHUN 2024. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

Introduction: Ischemic stroke is the most common type of stroke and a leading cause of disability and mortality, accompanied by an increasing prevalence of risk factors in the population. Hyperacute management focuses on restoring cerebral blood flow, dissolving thrombus, preventing re-occlusion, and preserving salvageable neural tissue. One recommended therapy is thrombolysis with alteplase (rtPA), which acts by activating the fibrinolytic system to convert plasminogen into plasmin. The effectiveness of thrombolysis can be assessed through changes in National Institute of Health Stroke Scale (NIHSS) value before and after treatment. Purpose: This study aimed to analyze the difference in NIHSS value in ischemic stroke patients before and after thrombolytic therapy at Fatmawati Central General Hospital in 2024. Methods: This study employed an analytical observational design with a retrospective cohort approach using secondary medical record data. A total of 39 patients met the inclusion criteria, and statistical analysis was conducted using the Wilcoxon test due to non-normal data distribution. Results: The median NIHSS value before therapy was 7 (IQR 6–11), while the post-thrombolysis value decreased to 6 (IQR 4–9) with p-value <0.05 (p-value = 0.001). Discussion: There was a significant statistical difference between NIHSS value before and after thrombolysis, indicating that thrombolysis improved neurological deficits in most patients. Conclusion: These findings reinforce that alteplase is an effective reperfusion therapy in the management of acute ischemic stroke.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2210211140] [Pembimbing 1: Riezky Valentina Astari] [Pembimbing 2: Adi Sukrisno] [Penguji: Arman Yurisaldi Saleh]
Uncontrolled Keywords: Ischemic Stroke, NIHSS, Thrombolysis, Alteplase, Fatmawati Hospital
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: SHARINA PUTRI WIDIYANI
Date Deposited: 05 May 2026 06:19
Last Modified: 05 May 2026 06:19
URI: http://repository.upnvj.ac.id/id/eprint/41121

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