Novia Tri Utami, . (2025) PENGARUH JENIS PELARUT EKSTRAKSI ULTRASONIK BIJI LABU KUNING TERHADAP KADAR TOTAL SENYAWA AKTIF DAN AKTIVITAS ANTIJAMUR Candida albicans. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Pumpkin seeds showed potential activity for antifungal agent against Candida albicans, a common pathogen causing candidiasis. Some metabolite such as tannins and phenols in these seeds play a crucial role due to their antifungal properties. These active compounds was extracted using methanol, ethyl acetate, and n-hexane as solvents. This research evaluates the effect of organic solvent type on the phenol and tannin content, also antifungal activity of pumpkin seed extracts obtained by ultrasonic extraction. Phenol and tannin content were determined using UV-Vis spectrophotometry, while the antifungal activity against Candida albicans was tested using the disk diffusion method. The extract obtained with methanol extract obtained the highest total tannin content 82,4254±0,00411 mg TAE/100g extract and the highest total phenol content of 40,3372±0,00685 mg GAE/100g extract. However, at a concentration of 4000 ppm, the methanol extract showed an inhibition zone 1,5967±0,1274 mm. The one-way ANOVA test statistically showed a significant difference in tannin and phenol levels among solvent treatments (P<0.05). Spearman's correlation indicated a strong positive and significant correlation (r=0.765, p<0.01) between extract concentration and inhibition zone diameter, it suggesting that the potential for antifungal activity might be more pronounced at higher concentrations. Keywords: Candida albicans, Cucurbita maxima, Phenol, Tannin, Solvent variation
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2110212028] [Pembimbing: Via Rifkia] [Penguji 1: Andiri Niza Syarifah] [Penguji 2: Rika Revina] |
| Uncontrolled Keywords: | Candida albicans, Cucurbita maxima, Phenol, Tannin, Solvent variation |
| Subjects: | Q Science > QD Chemistry Q Science > QK Botany Q Science > QR Microbiology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | NOVIA TRI UTAMI |
| Date Deposited: | 21 Aug 2025 03:20 |
| Last Modified: | 03 Sep 2025 07:29 |
| URI: | http://repository.upnvj.ac.id/id/eprint/38526 |
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