FLORENCIA YUWONO, . (2025) UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN DAN BUAH TANAMAN PARIJOTO (Medinilla speciosa B.) TERHADAP BAKTERI Shigella sonnei SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Bacillary dysentery is one of the infectious gastrointestinal diseases caused by Shigella sonnei, with increasing levels of antibiotic resistance, particularly in developing countries. Parijoto (Medinilla speciosa B.) is an endemic Indonesian plant traditionally used by local communities as a herbal and is known to possess potential antibacterial properties. This study aimed to evaluate the in vitro antibacterial activity of methanolic extracts of Parijoto leaves and fruits against Shigella sonnei. Extraction was carried out using the Ultrasonic-Assisted Extraction (UAE) method with methanol as the solvent. Antibacterial activity was tested using the disk diffusion method to observe inhibition zones, and the broth dilution method was used to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC), with extract concentrations ranging from 6.25 to 100 mg/mL. The results showed that both leaf and fruit extracts of Parijoto exhibited weak antibacterial activity against Shigella sonnei. The leaf extract showed its highest activity at a concentration of 25 mg/mL with a clear zone of 3.07 ± 0.12 mm, while the fruit extract demonstrated activity at 6.25 mg/mL with a clear zone of 1.7 ± 0.17 mm. However, MBC was not achieved for either extract. Statistical analysis revealed a significant difference (p < 0.05) in antibacterial activity between leaf and fruit extracts, with the leaf extract exhibiting greater effectiveness.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 2110212021] [Pembimbing: Annisa Farida Muti] [Penguji 1: Dhigna Luthfiyani Citra Pradana] [Penguji 2: Eldiza Puji Rahmi] |
| Uncontrolled Keywords: | Antibacterial, Inhibition zone Medinilla speciosa B., MBC, MIC, Shigella sonnei |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Farmasi (S1) |
| Depositing User: | FLORENCIA YUWONO |
| Date Deposited: | 21 Aug 2025 03:46 |
| Last Modified: | 21 Aug 2025 03:46 |
| URI: | http://repository.upnvj.ac.id/id/eprint/38354 |
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