POTENSI EKSTRAK DAUN SIRIH MERAH (Piper ornatum) TERHADAP PERBAIKAN GAMBARAN HISTOPATOLOGI ORGAN HATI TIKUS (Rattus norvegicus) GALUR WISTAR MODEL HIPERLIPIDEMIA

Al Fahri Dio Prayoga Ratta, . (2024) POTENSI EKSTRAK DAUN SIRIH MERAH (Piper ornatum) TERHADAP PERBAIKAN GAMBARAN HISTOPATOLOGI ORGAN HATI TIKUS (Rattus norvegicus) GALUR WISTAR MODEL HIPERLIPIDEMIA. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

ABSTRACT Purpose Nonalcoholic fatty liver disease (NAFLD) is a condition of accumulation of lipid levels in the liver. High-fat feed, dyslipidemia, obesity, and limited exercise are some of the factors that contribute to the development of NAFLD. High cholesterol levels can cause lipotoxicity, resulting in high levels of oxidative stress. Red betel leaves containing flavonoids, saponin, tannin, and alkaloid act as antioxidant and lower lipid levels in the body. Methodology This research is pure experimental with a posttest control group design consisting of 30 samples of white rat (Rattus norvegicus) Wistar strain. There will be six different groups, with three control groups and three treatment groups that will be given red betel leaf extract with 250, 500, and 750 mg/KgBW doses. One Way Annova continued with Post Hoc Tukey, which will be used to analyze cholesterol levels. Kruskall-Wallis continued with Post Hoc Mann Whitney, which will be used for histopathological images. Result Ethanol maceration of red betel leaf extract can decrease cholesterol levels and repair inflammation in the liver with 500 and 750 mg/KgBW doses. Conclusion Red betel leaf extract has potential benefits as an herbal leave for decreasing cholesterol levels and repairing liver damage caused by the accumulation of lipids.

Item Type: Thesis (Skripsi)
Additional Information: [No.Panggil: 2110211108] [Pembimbing 1: Maria Selvester] [Pembimbing 2: Meiska Bahar] [Penguji: Erna Harfiani]
Uncontrolled Keywords: Red Betel Leaves, Histopathology, Steatosis, Lobular Inflammation, Ballooning
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: AL FAHRI DIO PRAYOGA RATTA
Date Deposited: 18 Mar 2025 04:42
Last Modified: 18 Mar 2025 04:42
URI: http://repository.upnvj.ac.id/id/eprint/36352

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  • POTENSI EKSTRAK DAUN SIRIH MERAH (Piper ornatum) TERHADAP PERBAIKAN GAMBARAN HISTOPATOLOGI ORGAN HATI TIKUS (Rattus norvegicus) GALUR WISTAR MODEL HIPERLIPIDEMIA. (deposited 18 Mar 2025 04:42) [Currently Displayed]

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