Nela Azalina Aziz, . (2025) PENGARUH EKSTRAK BIJI ASAM JAWA (TAMARINDUS INDICA LINN.) TERHADAP PERTUMBUHAN MALASSEZIA FURFUR SECARA IN VITRO. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Malassezia furfur, which causes Pityriasis versicolor, may have experienced resistance to azole treatment as the first line of treatment for this disease. The solution to this problem is with alternative antifungal treatments from natural ingredients. The content of metabolite compounds in tamarind seeds (Tamarindus indica Linn.) has the potential to produce antifungal activity. This study aims to test the effect of tamarind seed extract (Tamarindus indica Linn.) on the growth of Malassezia furfur in vitro with experimental method and post test only control group design. Ethanol extracts of tamarind seeds at concentrations of 5%, 10%, 15%, and 20% were tested along with positive control ketoconazole 2% and negative control DMSO. Saboraud Dextrose Agar (SDA) medium was used for culturing M. furfur with the pitting method, followed by measurement of the clear zone at 24 hours and 48 hours incubation. Kruskall-Wallis test was used as data analysis with the results of significant inhibition differences, followed by Mann-Whitney Post Hoc test. The average measurement results of the inhibition zone of 24-hour incubation of 5%, 10%, 15%, and 20% concentrations were 8.65 mm, 9.35 mm, 11.4 mm, and 12.25 mm. Strong inhibition was produced in the administration of extract concentrations of 15% and 20% during the 24-hour incubation. Extract concentration, the amount of secondary metabolite compounds, and incubation time affect the inhibition zone produced. The most effective concentration is 15% concentration during 24-hour incubation with an inhibition zone of 11.4 mm. This is due to the content of secondary metabolite compounds including alkaloids, phenols, flavonoids, saponins, tannins, and terpenoids in tamarind seed extract.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil : 2110211083] [Pembimbing : Yuni Setyaningsih] [Penguji 1 : Fajriati Zulfa] [Penguji 2 : Ima Maria] |
| Uncontrolled Keywords: | Antifungal Activity, Tamarind Seed Extract, Malassezia Furfur |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RL Dermatology |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | NELA AZALINA AZIZ |
| Date Deposited: | 17 Mar 2025 03:59 |
| Last Modified: | 17 Mar 2025 03:59 |
| URI: | http://repository.upnvj.ac.id/id/eprint/34935 |
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