POTENSI EKSTRAK DAUN BIDARA (Ziziphus mauritiana Lam.) TERHADAP GAMBARAN HISTOPATOLOGI HATI TIKUS PUTIH GALUR WISTAR MODEL HIPERLIPIDEMIA

Detha Shanda, . (2023) POTENSI EKSTRAK DAUN BIDARA (Ziziphus mauritiana Lam.) TERHADAP GAMBARAN HISTOPATOLOGI HATI TIKUS PUTIH GALUR WISTAR MODEL HIPERLIPIDEMIA. Tesis thesis, Universitas Pembangunan Nasional Veteran Jakarta.

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Abstract

This study aims to access the potential of bidara leaf extract (Ziziphus mauritiana Lam.) on the histopathological features of white mice with hyperlipidemia. Twenty four male mice weighing 200 gram and about two month old were divided randomly into six different group, i.e: 1) Standard feed (K0); 2) High-fat diet (K1); 3) High-fat diet and Orlistat 2,16mg 3 times a day (K2); 4) High-fat diet and bidara leaf extract 0,2mg/kgBW (K3); 5) High-fat diet and bidara leaf extract 0,4mg/kgBW (K4); 6) High-fat diet and bidara leaf extract 0,8mg/kgBW (K5). Standard feed and High-fat diet were administrated for 49 days. Orlistat and bidara leaf extract were administrated from day 29 to day 49. Total of twenty four male mice were terminated and the livers were removed for H&E staining histopathological slides. Data on the degree of fatty liver and inflammation on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Ziziphus mauritiana Lam. Extract at a dose of 0,2mg/kgBW in group P1 and 0,8mg/kgBW in group P3 have the potential to improve the steatosis degree compared to high-fat feed mice in group K2 but does not have the potential to improve inflammation degree.

Item Type: Thesis (Tesis)
Additional Information: [No.Panggil:2010211065] [Pembimbing 1:Maria Selvester Thadeus} [Pembimbing 2:Aulia Chairani} [Penguji 1:Uswatun Hasanah]
Uncontrolled Keywords: histophatological, hyperlipidemia, high-fat diet, mice, Ziziphus mauritiana Lam.
Subjects: R Medicine > RB Pathology
Divisions: Fakultas Kedokteran > Program Studi Kedokteran (S1)
Depositing User: Detha Shanda
Date Deposited: 27 Mar 2024 13:07
Last Modified: 27 Mar 2024 13:07
URI: http://repository.upnvj.ac.id/id/eprint/28120

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