Ferdiana Laura Margareta, . (2021) POTENSI UMBILICAL CORD MESENCHYMAL STEM CELL (UC-MSC) PADA TERAPI RHEUMATOID ARTHRITIS (RA): Systematic Review. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation of the joints. Generally, this disease is suffered by elderly patients. However, it is possible to occur at a young age, such as juvenile rheumatoid arthritis (JRA), the most common type of arthritis in children and adolescents. Conventional therapies given to patients with rheumatoid arthritis to modulate the immune response, including disease-modifying anti-rheumatic drugs (DMARDS) and nonsteroidal anti-inflammatory drugs (NSAIDs), have limited therapeutic effects in RA patients. Long-term use of these drugs can cause side effects and resistance to therapy. In recent years mesenchymal stem cells (MSCs) are highly recommended therapy. They are considered promising because MSCs are potential immunomodulators that can differentiate into various cell types and stimulate tissue repair. These cells also have strong chemotactic abilities because they can migrate to damaged tissues and act as an anti-inflammatory. Therefore MSC is said to be suitable for autoimmune therapy, plus there has been a lot of research evidence (clinical trials) stating that there are no toxicity and side effects in the long term. One type of MSC based on its tissue source is umbilical cord mesenchymal stem cell which is believed to be the best among other types. This review discusses a UC-MSC-based therapeutic approach in children, adults, and the elderly focusing on published clinical data and clinical trials for the treatment of RA that are currently ongoing.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No.Panggil: 1810211024] [Penguji: Cut Fauziah] [Pembimbing 1: Yudhi Nugraha] [Pembimbing 2: Boenga Nurcita] |
| Uncontrolled Keywords: | UC-MSC, rheumatoid arthritis, juvenile idiopathic arthritis, safety, efficacy |
| Subjects: | L Education > L Education (General) R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RZ Other systems of medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Ferdiana Laura Margareta |
| Date Deposited: | 16 Feb 2022 11:50 |
| Last Modified: | 01 Mar 2022 03:59 |
| URI: | http://repository.upnvj.ac.id/id/eprint/15565 |
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