Pricilia Ardiani Pratiwi, . (2022) PENGARUH ZINK TERHADAP HISTOPATOLOGIS SPERMATOGENESIS MENCIT JANTAN (Mus musculus) DI INDUKSI OBAT ANTI KANKER CYCLOPHOSPHAMIDE. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Background : Cancer is a non-communicable disorder that may be a fitness trouble each withinside the global and in Indonesia. Treatment of most cancers these days may be performed in numerous ways, one in all that's chemotherapy. Chemotherapy is remedy the use of anti-most cancers tablets that goal to kill or sluggish the increase of most cancers cells. In its use, chemotherapy tablets have toxicity or aspect effects. A observe in 2017 giving cyclophosphamide, cisplatin, and doxorubicin brought about disturbances in rat spermatogenesis, inflicting infertility. Zn as an antioxidant, and performs an critical function in inhibiting ROS (Reactive Oxygen Species) in order that it could restore harm to spermatogenesis. Objective : To determine the effect of giving zinc to male mice (Mus musculus) intoxicated with the anti-cancer drug cyclophosphamide on the histopathological features of spermatogenesis. Methods : This examine used a real experimental put up check most effective manage group. The research subjects were male mice aged 6-8 weeks, body weight 20-30 grams (n=30) divided into 6 groups, namely K1 given 551 feed and drinking ad libitum; K2 is given Zn 100 mg/KgBW/day; K3 was given cyclophosphamide 200 mg//KgBW/day. K4, K5, and K6 were injected intraperitoneally with cyclophosphamide 200 mg/KgBW and given Zn at a dose (25,50,100 mg/KgBW). The treatment was carried out for 35 days.Then the mice were terminated and their testes were taken to make preparations with HE staining. Furthermore, the examination of spermatogenesis was carried out using the Johnsen score. Results : Based at the evaluation of the Kruskal-Wallis take a look at p = 0.0001 (p<0.05) there has been an impact of zinc management at the histopathological spermatogenesis of male mice (Mus musculus) precipitated through the anti-most cancers drug cyclophosphamide. The consequences of the Mann Whitney non- parametric distinction take a look at withinside the K4 and K6 corporations p = 0.035 (p <0.05) there has been a great impact among the management of zinc at a dose of 25 mg and one hundred mg. Conclusion : Administration of Zn to cyclophosphamide-intoxicated mice can reduce the histopathological disturbance of spermatogenesis.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil : 1710211092] [Pembimbing : Retno Yulianti] [Penguji : Maria Selvester Thadeus] |
| Uncontrolled Keywords: | Cyclophosphamide, Zn, Spermatogenesis. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Fakultas Kedokteran > Program Studi Kedokteran (S1) |
| Depositing User: | Pricilia Ardiani P |
| Date Deposited: | 07 Mar 2022 05:38 |
| Last Modified: | 07 Mar 2022 05:40 |
| URI: | http://repository.upnvj.ac.id/id/eprint/15330 |
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