Alya Andina Dasuki, . (2021) FAKTOR RESIKO KEJADIAN PENINGKATAN KADAR TRANSAMINASE PADA PENGGUNAAN OBAT ANTI TUBERKULOSIS PASIEN TUBERKULOSIS PARU RST WIJAYAKUSUMA PURWOKERTO TAHUN 2020. Skripsi thesis, Universitas Pembangunan Nasional Veteran Jakarta.
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Abstract
Most of the tuberculosis cases reported in Indonesia were in provinces with high population density, including Central Java. The combination of first-line antituberculosis drugs including pyrazinamide, isoniazide and rifampicin has the potential to cause hepatotoxicity as indicated by an increase in transaminase levels. Incidence of elevated transaminase levels leading to drug resistance and treatment failure. Early detection of elevated transaminase levels by antituberculosis drugs is important by studying predisposing risk factors. The purpose of this study was to determine the relationship between risk factors and the incidence of increased levels of transaminases due to the use of anti-tuberculosis drugs in patients with pulmonary tuberculosis at RST Wijayakusuma Purwokerto. This type of research is an observational analytic study with a cross-sectional design. A total of 80 samples were selected by random sampling. Data collection is done by viewing and recording the patient's medical record. Data were analyzed using the Chi-squared test and Logistic Regression test. The results of the bivariate analysis with the Chi-Square test showed that there was a significant relationship between old age (p = 0,000), female gender (p = 0.035), malnutrition (0,000), length of treatment (p = 0.026) and a history of taking other drugs. (p = 0.008). The most influential factor was the elderly (OR = 8.815) on the incidence of elevated transaminase levels.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | [No. Panggil : 1710211050] [Pembimbing : Annisa Farida Muti] [Penguji 1 : Hany Yusmaini] |
| Uncontrolled Keywords: | Tuberculosis, hepatotoxicity, therapeutic drug monitoring, risk factor |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RZ Other systems of medicine |
| Divisions: | Fakultas Kedokteran > Program Studi Pendidikan Profesi Dokter |
| Depositing User: | Alya Andina Dasuki |
| Date Deposited: | 10 Mar 2021 04:55 |
| Last Modified: | 25 May 2022 03:43 |
| URI: | http://repository.upnvj.ac.id/id/eprint/9313 |
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